基础胰岛素与预混胰岛素联合口服降糖药治疗2型糖尿病临床疗效比较

目的探讨基础胰岛素与预混胰岛素联合口服降糖药在2型糖尿病患者的临床疗效。方法将42例2型糖尿病患者随机分为联合基础胰岛素治疗组和联合预混胰岛素对照组,每组21例。2组患者均给予常规治疗,口服降糖药物、调节血脂、控制饮食和体质量。联合基础胰岛素治疗组在常规治疗基础上皮下注射基础胰岛素。联合预混胰岛素对照组在常规治疗基础上皮下注射预混胰岛素(30R)。检测治疗前后空腹血糖(FBG)、餐后2 h血糖(2hPG)水平,高压液相法测定HbAlc(糖化血红蛋白)水平。比较2组胰岛素注射剂量,观察血糖达标和低血糖事件发生情况。结果与治疗前比较,2组治疗后FBG、2hPG、HbAlc水平均明显降低,联合基础胰岛素治疗组降低的更加明显。联合基础胰岛素治疗组胰岛素用量显著少于联合预混胰岛素对照组。2组患者治疗过程中出现低血糖事件均为轻度,进食后可缓解。结论基础胰岛素联合口服降糖药控制FPG、HbAlc效果较好,胰岛素用量较少。

Comparison on the application of basal insulin and premixed insulin respectively combined with oral hypoglycemic agents in patients with type 2 diabetes mellitus

Objective To investigate the clinical effects of basal insulin and premixed insulin respectively combined with oral hypoglycemic agents in the patients with type 2 diabetes mellitus(T2DM).Methods FortyA1.two patients with T2DM were randomly divided into treatment group combined with basal insulin and control group combined with premixed insulin,21 cases in each group.Patients in both two groups received routine treatment,including oral hypoglycemic agents(OHA),regulation of blood lipid and control of diet and body weight.The treatment group combined with basal insulin was subcutaneously injected basal insulin in addition to the routine treatment,while the control group combined with premixed insulin injected premixed insulin(30R).The levels of fasting blood glucose(FBG) before and after treatment and 2A1.hour postprandial blood glucose(2hPG) were detected,and the level of glycosylated hemoglobin(HbAlc) was determined by microcolulmn method.The doses of insulin injection were compared in the two groups,and the recovery of blood glucose and occurrence of hypoglycemia were observed.Results Compared with before treatment,the levels of FBG,2hPG and HbAlc all conspicuously decreased in both groups,and the decreased range of treatment group combined with basal insulin was larger.The insulin dose of treatment group combined with basal insulin was significantly less than that of the control group combined with premixed insulin.During the treatment,patients in both groups suffered from mild hypoglycemia and alleviated after taking food.Conclusion In the aspects of controlling FPG and HbAlc,the therapeutic effects of basal insulin combined with OHA are better,and insulin dose is less.