生长激素受体及胰岛素样生长因子1受体在肾透明细胞癌中的表达及意义 |
| |
作者姓名: | 谢传昊 张朝华 张丽军 邵丽军 |
| |
作者单位: | 承德医学院研究生院;保定市第一医院泌尿外科;利辛县人民医院泌尿外科 |
| |
摘 要: | 目的:探讨生长激素受体(growthhormonereceptor,GHR)和胰岛素样生长因子1受体(insulin-likegrowthfactor-1receptor,IGF-1R)在肾透明细胞癌组织和癌旁正常组织中的表达情况及意义。方法:采用免疫组织化学ABC法检测64例肾透明细胞癌患者的癌组织和癌旁正常组织的GHR和IGF-1R的表达情况,分析GHR和IGF-1R与肾透明细胞癌的病理分级、临床分期及肿瘤发生、发展和转移的关系。结果:GHR和IGF-1R在肾透明细胞癌的阳性表达率分别为62.50%(40/64)和75.00%(48/64),明显高于癌旁组织43.75%(28/64)和54.69%(35/64)(均P<0.05);且GHR和IGF-1 R在肾透明细胞癌组织的表达水平与肿瘤的病理分级和临床分期有关(均P <0. 0 5),与年龄及性别无相关性(均P>0.05)。GHR和IGF-1R在肾透明细胞癌组织中的表达呈线性正相关(P<0.01)。结论:GHR和IGF-1R在肾透明细胞癌组织中高表达,且两者呈线性正相关,提示GHR和IGF-1R对肾透明细胞癌的增殖起重要作用,为肾透明细胞癌的治疗提供理论依据。
|
关 键 词: | 生长激素受体 胰岛素样生长因子1受体 肾透明细胞癌 免疫组织化学 |
Expression of GHR and IGF-1R and their significance in renal clear cell carcinoma |
| |
Authors: | XIE Chuanhao ZHANG Chaohua ZHANG Lijun SHAO Lijun |
| |
Institution: | (Graduate School,Chengde Medical University,Chengde Hebei 067000;Department of Urology Surgery,Baoding No.1 Hospital,Baoding Hebei 071000;Department of Urology Surgery,Lixin People’s Hospital,Lixin Anhui 236700,China) |
| |
Abstract: | XIE Chuanhao;ZHANG Chaohua;ZHANG Lijun;SHAO Lijun(Graduate School,Chengde Medical University,Chengde Hebei 067000;Department of Urology Surgery,Baoding No.1 Hospital,Baoding Hebei 071000;Department of Urology Surgery,Lixin People’s Hospital,Lixin Anhui 236700,China) |
| |
Keywords: | growth hormone receptor insulin-like growth factor-1 receptor renal clear cell carcinoma immunohistochemistry |
本文献已被 CNKI 维普 等数据库收录! |
|