Evaluation of hematologic factors and bilirubin following exchange transfusion in neonatal hyperbilirubinemia |
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| Institution: | 1. Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Nursing, School of Medical Sciences, Islamic Azad University, Mashhad Branch, Mashhad, Iran;3. Student of PhD, Department of Pediatric Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran;4. Department of Midwifery, School of Medical Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran;1. Transfusion Medicine & Blood Centre, Sarvodaya Hospital & Research Centre, Faridabad, Delhi NCR, India;2. Medical Oncology & Hematology, Sarvodaya Hospital & Research Centre, Faridabad, Delhi NCR, India;3. Medical Administration, Sarvodaya Hospital & Research Centre, Faridabad, Delhi NCR, India;1. Department of Transfusion Medicine, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai 410210, India;1. Haematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain;2. Instituto de Investigación Sanitaria (ISS) Hospital La Fe, Valencia, Spain;3. School of Medicine and Dentistry, Catholic University of Valencia, Valencia, Spain;4. CIBERONC, Instituto Carlos III, Madrid, Spain;1. Servizio di Immunoematologia e Medicina Trasfusionale, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy;2. Bone Marrow Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy |
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| Abstract: | IntroductionExchange transfusion (ECT) is one of effective treatments for rapid reduction of the bilirubin serum levels. The main purpose of this study was to offer greater insights into the effects of ECT on the hematologic factors and bilirubin in neonatal hyperbilirubinemia.MethodsThis cross-sectional study was performed on 380 neonates over 35 gestational weeks, and 2–14 days old with a bilirubin of above 17 mg/dl who had undergone ECT at Ghaem Hospital of Mashhad in Iran from 2011 to 2021. Blood samples were examined before, immediately after, 6 h and 60 h after ECT for complete blood cell count (CBC), platelet count and bilirubin serum level analysis.ResultsIn this study, the mean age of neonates was 5.21 ± 3.55 days with a mean birth weight of 2810 ± 710 gr. The mean platelet count (PLT), white blood cell (WBC) and the serum level of bilirubin were estimated at 260,000/mm2, 12,400/mm2, 23 mg/dl before ECT and 97,000/mm2, 7370//mm2 and 12.6 mg/dl immediately after ECT, respectively (P-value <0.001).ConclusionThe results indicated that the mean serum levels of bilirubin, platelets, and leukocytes dropped to 55%, 30%, and 60% of their baseline levels before ECT, respectively, but they all spiked after ECT. |
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| Keywords: | Bilirubin Exchange transfusion Hematologic factors Neonatal hyperbilirubinemia Platelet count White blood cell |
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