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维持性血液透析患者微炎症状态与营养不良关系
引用本文:姚少峰,周健美,袁自宏.维持性血液透析患者微炎症状态与营养不良关系[J].实用诊断与治疗杂志,2007,21(11):833-834.
作者姓名:姚少峰  周健美  袁自宏
作者单位:芜湖市皖南医学院弋矶山医院血液净化中心,安徽省,241000
摘    要:目的探讨维持性血液透析患者微炎症与营养状况的关系.方法测定47例尿毒症血液透析患者透析前静脉血C反应蛋白、白细胞介素-6、血清前白蛋白、血清白蛋白、血红蛋白、胆固醇、尿素氮、肌酐等生化指标.结果相关性分析表明,C反应蛋白与血清白蛋白、前白蛋白水平呈现明显负相关(r=-0.251,P<0.05;r=-0.343,P<0.01);白蛋白与前白蛋白、肌酐水平、年龄呈现正相关(r=0.734,P<0.01;r=0.393,P<0.01;r=0.410,P<0.01),与透析龄呈现负相关(r=-0.349,P<0.05),与IL-6无显著相关性.结论C反应蛋白是反映维持性血液透析患者微炎症反应较好的预测指标,而微炎症反应对血透患者营养不良起着重要的影响.

关 键 词:血液透析  微炎症  C-反应蛋白  白细胞介素-6  营养不良
文章编号:1672-3457(2007)11-833-02
修稿时间:2007-05-23

Association of inflammation and malnutrition in maintenance hemodialysis patients
YAO Shaofeng,ZHOU Jianmei,YUAN Zihong.Association of inflammation and malnutrition in maintenance hemodialysis patients[J].Journal of Practical Diagnosis and Therapy,2007,21(11):833-834.
Authors:YAO Shaofeng  ZHOU Jianmei  YUAN Zihong
Institution:Blood Punfication Center,Yijianshan Hospital Affiliated to Wannan Medical College,Wuhu 241000,China
Abstract:Objective To investigate the relationship between inflammation and malnutrition in maintenance hemodialysis patients.Methods Serum C-reactive protein,interleukin-6,serum creatinine,albumin,cholesterol,prealbumin and hemoglobin were measured before hemodialysis in 47 maintenance hemodialysis patients.Results Negative correlation was found between the C-reactive protein and ALB and PA in 47 maintenance hemodialysis patients(r=0.251,P<0.05;r=0.343,P<0.01).Positive correlation was found between ALB and PA,Scr,ege in these patients(r=0.734,P<0.01;r=0.393,P<0.01;r=0.410,P<0.01).Negative correlation was aslo found between ALB and the time on dislysis in 47 maintenance hemodialysis patients(r=-0.349,P<0.05).No correlation was found between ALB and IL-6 in the patients.Conclusion C-reactive protein can be used as a good marker of inflammation in hemodialysis patients.Inflammation plays an important role in malnutrition in maintenance hemodialysis patients.
Keywords:Hemodialysis  inflammation  C-reactive protein  interleukin-6  malnutrition
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