慢性阻塞性肺疾病患者血气分析与血浆纤维蛋白原的相关性研究

目的：探讨慢性阻塞性肺疾病患者血浆纤维蛋白原（FIB）水平及与血气分析相关性。方法：对30例慢性阻塞性肺疾病患者治疗前后血气分析、血浆纤维蛋白原及30例对照组的血浆纤维蛋白原分别进行测定。结果：血浆纤维蛋白原水平在慢性阻塞性肺疾病加重期患者明显升高，与对照组相比有显著性差异；治疗后血浆纤维蛋白原明显下降，与对照组相比无显著性差异；血浆纤维蛋白原与动脉血氧分压（PaO2）呈负相关。血浆纤维蛋白原与动脉血二氧化碳分压（PaCO2）呈正相关。结论：慢性阻塞性肺疾病患者血浆纤维蛋白原增高，可导致血液高凝状态，并易导致肺小动脉血栓形成、低氧血症和高碳酸血症。临床应改善缺氧、通气及适当的抗凝治疗对控制病情有益。

Correlative study on blood gas analysis and plasma fibrinogen level in the patients with chronic obstructive pulmonary disease

Objective To study the change of plasma fibrinogen and correlation with blood gas analysis in the patients with chronic obstructive pulmonary disease. Methods The plasma fibrinogen level was measured in 30 patients with chronic obstructive pulmonary disease and 30 controls. Blood gas analysis was measured in 30 patients with chronic obstructive pulmonary disease. Results The plasma fibrinogen level was apparently higher in exacerbated patients than in controls. After treatment, the plasma fibrinogen level was significantly low,but there was no significantly difference as compared with controls. The plasma fibrinogen level was negatively correlated with PaO2. The plasma fibrlnogen level was positively correlated with PaCO2. Conclusion The Elevated plasma fibrinogen level may be associated with hypercoagulability state of chronic obstructive pulmonary disease and contributes to thrombi in small pulmonary arteries and arterioles. Hypoxemia and hypercapnia were correlated with the elevated plasma fibrinogen level. The improvement of hypoxemia, ventilation and the anti-coagulability medicine treatment are benefit for chronic obstructive pulmonary disease patients.