癌抗原在胸腹腔积液及相关疾病诊断与治疗中的应用

目的：探讨癌抗原125在胸腹腔积液及相关肝胆、肺及心血管疾病中的临床价值。方法：采用美国Bayer全自动化学发光免疫分析法测定健康对照组及患者血清标本的癌抗原125、癌胚抗原含量，并用日本OLYMPUS全自动生化分析仪检测相应患者血清γ-谷氨酰转肽酶的含量。结果：癌抗原125升高次序为：腹水、胸水、胸腔恶性肿瘤、心力衰竭、腹腔积液-血清、肝硬化、胸腔积液-血清、肺癌、肝癌／胆管癌。癌抗原125在胸腔积液、腹腔积液患者胸水、腹水比血清升高更显著。肺癌、肺炎患者血清癌抗原125联合测定癌胚抗原可鉴别诊断。对肝胆疾病联合测定血清癌胚抗原、γ-谷氨酰转肽酶可提高阳性率。心脑血管疾病主要是心力衰竭癌抗原125升高。结论：血清癌抗原125在良性与恶性疾病中均有升高，在胸腔积液、腹腔积液升高显著。肝硬化癌抗原125升高，肝癌癌胚抗原升高。

Application on determination of CA125 in hydrothorax, hydroperitoneum and correlation diseases

Objective To observe the clinical value of CA125 in hydrothorax,hydroperitoneum,hepatic,lung,cardiovescular disease.Methods CA125 and CEA of healthy group patients were assessed with Bayer ACS180SE chemiluminescent immunoassay made in USA,and the GGT were detected with Japanese OLYMPUS AU2700 biochemistry analyzer.Results CA125 was increased in the order of peritoneal fluid,pleural,malignant tumor of thoracic cavity,heart failure,abdominal cavity accumulate fluid(serum),hepatocirrhosis,hydrothorax(serum),lung cancer and hepatoma/cholangitis.Compared with the corresponding serum CA125 level of pleural fluid,peritoneal fluid was higher.Detecting CA125 and CEA could make differentiate diagnosis of lung cancer from pneumonia.Combining CA125,CEA and GGT could improve positive rate.CA125 of heart failure was increased too.Conclusion Serum CA125 is increased in benign or malignancy diseases,especially in hydrothorax and hydroperitoneum.CA125 is increased in hepatocirrhosis and CEA is increased in hepatocarcinoma.