原发皮肤结外NK/T细胞淋巴瘤一例并文献复习

报道1例原发皮肤结外NK/T细胞淋巴瘤,并复习文献。患者,女,42岁。全身皮肤瘀斑、皮下结节20余天,发热4 d。右股内侧皮损组织病理示:大量淋巴细胞及浆细胞呈弥漫性浸润。免疫组化结果:CD3、CD43、CD56、颗粒酶B(Granzyme B,GгB)、细胞毒性蛋白(TIA)-1均(+)、Ki-67 LI约60%阳性;原位杂交EBER(+)。本病恶性程度高,需尽早进行组织病理检查及免疫组化染色以帮助诊断。

Primary cutaneous extranodal NK/T-cell lymphoma:a case report

To report a case of primary cutaneous extranodal NK/T-cell lymphoma, and the pertinent literature was reviewed. The patient was 42-year-old, female, who suffered from subcutaneous nodules and ecchymosis for 20 days, and recurrent fever for 4 days. Dermatopathology examination showed that there was a widespread infiltration of lymphoid cells; immunohistrochemistry examination results showed that CD3, CD43, CD56, GгB and TIA-1 were positive; Ki-67 LI was about 60% positive; EBER detected by in situ hybridization was positive. The diagnosis was primary cutaneous extranodal NK/T cell lymphoma, which is a high-grade malignancy. The histopathology and immunohistochemistry examination should be carried out as soon as possible so as to get the deifnite diagnosis.