Low dose prednisolone or oestrogen in the treatment of women with late onset or persistent acne vulgaris |
| |
Authors: | CR DARLEY JW MOORE GM BESSER DD MUNRO JD KIRBY |
| |
Institution: | Departments of Dermatology and Endocrinology, St Bartholomew's Hospital, London ECI;Department of Clinical Endocrinology, Imperial Cancer Research Fund, Lincolns Inn Fields, London WCI |
| |
Abstract: | Women with persistent or late onset acne vulgaris were divided into two treatment groups. The first received continuous low dose prednisolone to suppress ACTH-dependent androgen secretion and the second was treated with cyclical oestrogens with medroxyprogesterone to elevate sex hormone binding globulin (SHBG). In both groups there was a significant improvement in the severity of the acne after 4 months’treatment. Although pre-existing hormonal abnormalities were corrected, the improvement in the acne did not correlate with the baseline hormone levels. However, suitable oestrogen-progesterone combinations or low dose prednisolone may be given, alone or in combination, to suppress free circulating androgens in these patients with a high probability of improving their acne. |
| |
Keywords: | |
|
|