外阴阴道念珠菌病的病因研究及体外药敏检测

目的了解福州地区阴道念珠菌病的病因、致病菌的菌种特征。方法采用科玛嘉念珠菌显色培养基和YBC鉴定卡及API-20C AUX酵母菌鉴定系统对门诊就诊661例患者阴道分泌物分离到的332株致病真菌进行鉴定,并采用ROSCO纸片扩散法对4种抗真菌药进行药物敏感检测。结果总感染率为69.45%共分离菌种6种。339株念珠菌,其中白念珠菌为288株占85%,光滑念珠菌23株占6.8%,热带念珠菌12株占3.54%,克柔念珠菌7株占2%,近平滑念珠菌4株占1.18%,光滑假丝酵母菌4株占1.18%,酿酒酵母菌1株占0.29%。结论本地区念珠菌性阴道炎主要的病原菌以白色念珠菌为主,其次是光滑念珠菌、热带念珠菌。

Analysis on the pathogens and fungi susceptibility test in vitro of patients with vulvovaginal candidiasis

Objective To analyze the pathogens of Vulvovaginal candidiasis in FuZhou. Methods 332 strains isolated from vaginal secretions of 661 patients with vulvovaginal candidiasis in our department were identified with CHROMagar candida chromogenic culture medium,YBC method and API20C AUX. The susceptibility test of 4 antifungal drugs was tested by ROSCO disk diffusion method. Results The total infection rate was 69.45%. In 339 strains of candida albicans, there were 288 stains of candida albicans （85%）, 23 stains of candida glabrata （6.8%）, 12 strains of candida tropicalis （3.54%）, 7 strains of candida krusei （2%）, 4 strains of candida parapsilosis （1.18%）, 4 strains of Candida glabrata （1. 18% ） and 1 strain of saccharomyees eerevisiae （0.29%）. Conclusion The major pathogens of vulvovaginal candidiasis is candida albicans, candida glabrata and eandida tropicalis in Fuzhou.