六种抗菌药物体外对解脲支原体与人型支原体的抗菌作用

采用琼脂对倍稀释方法，测定了６种国产抗菌药物对３０株解脲支原体（Ｕｕ）、３０株人型支原体（Ｍｈ）体外抗菌作用效果。结果显示：乙酰螺旋霉素、氟哌酸和强力霉素有较强的抗Ｕｕ与Ｍｈ作用。乙酰螺旋霉素抗 Ｕｕ的 ＭＩＣ５０与 ＭＩＣ９０为０． ２５ｍｇ／Ｌ与１ｍｇ／Ｌ，抗Ｍｈ为０． ５ｍｇ／Ｌ与１ｍｇ／Ｌ。氟哌酸抗 Ｕｕ与Ｍｈ作用相同，ＭＩＣ５０与ＭＩＣ９０为０．５ｍｇ／Ｌ与１ｍｇ／Ｌ。强力霉素抗Ｕｕ的ＭＩＣ５０与ＭＩＣ９０为０．５ｍｇ／Ｌ与１ｍｇ／Ｌ，抗Ｍｈ为０．２５ｍｇ／Ｌ与２ｍｇ／Ｌ。Ｍｈ对红霉素有高度抵抗作用，ＭＩＣ５０与ＭＩＣ９０为６４ｍｇ／Ｌ与１２８ｍｇ／Ｌ。６株 Ｕｕ、４株Ｍｈ对四环素高度耐药，ＭＩＣ５０与 ＭＩＣ９０分别为６４ｍｇ／Ｌ与１２８ｍｇ／Ｌ和１６ｍｇ／Ｌ与３２ｍｇ／Ｌ，但对其它抗菌药物敏感。小檗硷抗Ｕｕ与Ｍｈ作用相同，ＭＩＣ５０与ＭＩＣ９０为４ｍｇ／Ｌ与８ｍｇ／Ｌ，对耐四环素的Ｕｕ与Ｍｈ也有相同的抗菌作用。

In Vitro Antibacterial Activities of 6 Antimicrobial Agents Against Ureaplasma Urealyticum and Mycoplasma Hominis

In this report,in vitro antibacterial activities of 6 antimicrobial agents against 30 strains of Urea plasma urealyticum (Un), 30 strains of Mycoplasma hominis (Mh)were determined using agar dilution method. The results indicated that acetylspiramycin,norfloxacin and doxycycline are highly active against Uu and Mh. Acetylspiramycin is active against Uu, MIC50 0. 25mg/L, and MIC90 1mg/L, against Mh, MIC50 0. 5mg/L and MIC90 1mg/L. Norfloxacin is equally ac- tive against Un and Mh, MICS, 0.5mg/L and MIC50 1mg/L. Doxycycline is active against Uu and Mh, for Un MIC50 is 0. 5mg/L and MIC90 1mg/L,and for Mh MIC50 is 0. 25 and MIC90 2mg/L.Mh is resistant to erythromycin (MIC50 60mg/L and MIC90 128mg/L). Six strains of Un and 4 strains of Mh are highly resis- tant to tetracycline (MIC50 64 to 128mg/L and MIC90 16 to 32mg/L)and yet still sensitive to the other an- timicrobial agents. Berberine is equally active against Uu and Mh (MIC50 4mg/L and MIC90, 8mg/L) and is effective for the tetracycline resistant strains of Uu and Mh.