克隆性T细胞受体基因重排检测在皮肤T细胞淋巴瘤中的应用

 

年，卷(期)：

2009, 26(5) 

分类号：

R739.5 

关键词：

淋巴瘤    T细胞    皮肤    基因重排    抗原受体   

机标分类号：

R73 R39 

机标关键词：

克隆性细胞受体基因重排检测皮肤淋巴瘤细胞淋巴瘤单个淋巴细胞特异性识别组织淋巴判断预后机制研究分化过程恶性增殖诊断失调能力抗原疾病发病病变 

基金项目：

 

DOI：

 

参考文献(24条)

1. HODGES E,KRISHNA M T,PICKARD C,et al.Dignostic role of tests for T cell receptor(TCR)genesJ].J Clin Pathol,2003,56(1):1-11.
2. SANDBERG Y,VAN GASTEL-MOL EJ,VERHAAF B,et al.BIOMED-2 multiplex multiplex immunoglobulin/T-cell receptor polymerase chain reaction protocols can reliably replace Southern blot analysis in routine clonality diagnosticsJ].J Mol Diagn,2005,7(4):495-503.
3. 闫庆国,黄高昇,王哲,等.BIOMED-2标准化的1G/TCR基因重排克隆性分析系统及其应用研究J].诊断病理学杂志,2008,4(15):307-309.
4. 李挺,祖幼立.抗原受体基因重排克隆性分析淋巴瘤辅助诊断技术的发展和应用现状J].北京大学学报(医学版),2008,4(40):343-346.
5. L KANDOLF.TCRγ gene rearrangement analysis in skin samples and peripheral biood of mycosis fungoides patientsJ].Acta Dermatoren APA.2007,16(4):149-155.
6. 王平,陈明华,等.原发性皮肤T细胞淋巴瘤外周血克隆性T细胞的检测与研究J].临床皮肤科杂志,1999,28(3):156-158.
7. SLATER DN.Review of investigative diagnostic techniques for cutaneous lymphomaJ].Semin Dermatol,1994,13(3):166-171
8. 邱丙森.原发性皮肤T细胞淋巴瘤T细胞受体基因重排检测J].临床皮肤科杂志,2001,30(2):60-61.
9. STEVENS SR,KE MS,BIROL A,et al.A simple clinical scoring system to improve the sensitivity and standardization of the diagnosis of mycosis fungoides type cutaneous T-cell lymphoma:logistic regression of clinical and laboratory dataJ].Br J Dermatol,2003,149(3):513-522.
10. 万川,徐晨,王琳,等.皮下脂膜炎样T细胞淋巴瘤的免疫表型、基因重排检测及其在诊断中的意义J].中华病理学杂志,2008,37(6):390-394.
11. 胡炜炜,劳力民.皮下脂膜炎样T细胞淋巴瘤研究进展J].国际皮肤性病学杂志,2006,32(5):294-296.
12. 孔蕴毅,王坚,束木娟,等.原发性皮肤间变性大细胞淋巴瘤T细胞受体、IgH基因重排J].临床皮肤科杂志,2005,34(1):3-6.
13. 昌红,张建英,高颖,等.原发皮肤淋巴瘤临床病理学研究J].医学临床研究.2008,4(25):590-597.
14. 薛峰,沈小雁,施若非,等.皮肤T细胞淋巴瘤皮损与外周血中TCRγ基因重排的检测J].临床皮肤科杂志,2008,12(37):766-768.
15. MAGRO CM,NUOVO GJ,CROWSON AN.The utility of the in situ detection of T-cell receptor Beta rearrangements in cntaneous T-cell-dominant infiltratesJ].Diagn Mol Pathol,2003,12(3):133-141.
16. HSIAO PF,HSIAO CH,LIN YC,et al.Histopathologic-mo-lecular Correlation in Early Mycosis Fungoides Using T-cell Receptor γ Gene Rearrangement by Polymerase Chain Reaction with Laser Capture MicrodissectionJ].Formos Med Assoc,2007,4(106):265-272.
17. VEGA F,LUTHRA R,MEDEIROS LJ,et al.Clonal heterogeneity in mycosis fungoides and its relationship to clinical courseJ].Blood,2002,100(9):3369-3373.
18. WOOD GS.T-cell receptor and immunoglobulin gene rearrangements in diagnosing skin diseaseJ].Arch Dermatol,2001,137(11):1503-1506.
19. FRASER-ANDREWS EA,Russell-Jones R,WOOLFORD AJ.et al.Diagnostic and prognostic importance of T-cell receptor gene analysis in patients with Sezary syndromeJ].Cancer,2001,92(7):1745-1752.
20. JUAREZ T.ISENHATH SN,POLISSAR NL,et al.Analysis of T-cell receptor gene rearrangement for predicting clinical outcome in patients with cutaneous T-cell lymphoma:a comparison of Southern blot and polymerase chain reaction methodsJ].Arch Dermatol,2005,141(9):1107-1113.
21. ASSAF C,HUMMEL M,STEINHOFF M,et al.Early TCR-beta and TCR-gamma PCR detection of T-cell clonality indicates minimal tumor disease in lymph nodes of cutaneous Tcell lymphoma:diagnostic and prognostic implicationsJ].Blood,2005,105(2):503-510.
22. PONTI R,QUAGLINO P,NOVELLI M,et al.T-cell receptor gamma gene rearrangement by multiplex polymerase chain reaction/heteroduplex analysis in patients with cutaneous Tcell lymphoma(mycosis fungoides/Sézary syndrome)and benign inflammatory disease:correlation with clinical,histological and immunophenotypical findingsJ].Br J Dermatol,2005,153(3):565-573.
23. VEELKEN H,WOOD GS,SKLAR J.Molecular staging of cutaneous T-cell lymphoma:evidence for systemic involvement in early diseaseJ].J Invest Dermatol,1995,104(6):889-894.
24. LINNEMANN T,GELLRICH S,LUKOWSKY A,et al.Polyclonal expansion of T cells with the TCR V beta type of the tumour cell in lesions of cutaneous T-cell lymphoma:evidence for possible superantigen involvementJ].Br J Dermatol,2004,150:1013-1017.

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