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化疗对高危因素子宫内膜癌患者预后及生活质量的影响
引用本文:李耀,王兴红.化疗对高危因素子宫内膜癌患者预后及生活质量的影响[J].中国性科学,2014(7):32-34.
作者姓名:李耀  王兴红
作者单位:玉林市妇幼保健院妇产科,广西玉林537000
摘    要:目的:分析化疗在子宫内膜癌预后及生活质量的影响.方法:将116例具有子宫内膜癌患者按照患者知情自愿原则分为对照组(n =69例)与观察组(n=47例).对照组患者进行单独手术治疗,观察组患者在手术治疗基础上进行化疗,观察两组患者术前、术后3个月的CA-125水平、随访5年生存率及比较两组患者术前及术后6个月时的生存质量状况.结果:观察组术后3个月时的CA125水平为(21.4±8.9 U/mL vs 46.17±11.3U/mL),术后1年时的CA-125水平为(22.60±9.3 U/mL vs 42.19±14.21U/mL)P<0.05,观察组的5年生存率为87.2%,对照组为66.7%,两者比较,x2=4.766,P=0.029;观察组与对照组患者术后6个月时的FACT-G生存质量评分(64.89±8.60分vs 48.61±8.24分),术后1年的FACT-G生存质量评分(61.89±7.03分vs 46.78±6.42分),P<0.05.结论:化疗对于具有高危因素的子宫内膜癌具有提升5年生存及改善生活质量作用,临床上对于高危因素的子宫内膜癌应尽可能推荐使用辅助化疗.

关 键 词:化疗  子宫内膜癌  预后  生活质量

Impact of Chemotherapy on the prognosis and life quality of patients with surgical treatment of endometrial cancer
LI Yao,WANG Xinghong.Impact of Chemotherapy on the prognosis and life quality of patients with surgical treatment of endometrial cancer[J].The Chinese Journal of Human Sexuality,2014(7):32-34.
Authors:LI Yao  WANG Xinghong
Institution:. (Department of Obstetrics and Gynecology, Maternal and Child Health Hospital, Yulin 537000, China)
Abstract:Objectives: To analyze the impact of chemotherapy on the prognosis of endometrial cancer and quality of life. Methods: 116 patients with endometrial cancer were divided into control group (n = 69) and observation group ( n = 47) in accordance with the principle of voluntary informed. Patients in the control group were given surgery alone and patients in the observation group received additional chemotherapy. The CA 125 level before and 3m after the treatment, 5 -year survival rate, and quality of life before and 6m after the treatment of the groups were compared. Results: The CA125 level 3m after the operation (21.4 ± 8.9 U/mL vs 46. 17 ±11.3U/mL) and a year after the operation (22. 60 ± 9. 3 U/mL vs 42. 19 ± 14. 21U/mL) and 5 - year survival rate ( 87.2 % vs 66.7% , )(2 = 4. 766, P = 0. 029) of the two groups were of significant difference. The FACT - G score on quality of life 6m after the operation (64. 89 ±8.60 vs 48 . 61 ±8.24) and a year after the operation (61.89±7.03 vs 46.78 ± 6. 42) were of significant difference ( P 〈 0.05 ). Conclusion: Chemotherapy can improve the 5 - year survival rate and quality of life for patients with high risks for endometrial cancer and adjuvant chemotherapy should be rec- ommended to such patients.
Keywords:Chemotherapy  Endometrial cancer  Prognosis  Quality of life
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