桂枝加龙骨牡蛎汤加味对心肾不交型早泄瘦素、5-羟色胺影响及疗效研究

目的:探讨桂枝加龙骨牡蛎汤加味对心肾不交型早泄瘦素、5-羟色胺影响及疗效。方法:将72例心肾不交型早泄患者,随机分为桂枝加龙骨牡蛎汤加味组(A组)24例、金锁固精丸组(B组)24例、曲唑酮组(C组)24例。三组分别用药,疗程为4周,停药后4周随访。比较三组治疗效果,比较三组治疗前及治疗后8周的平均阴道内射精潜伏期(IELT)以及早泄诊断量表(PEDT)中的各项指标情况,比较三组治疗前后的血清瘦素(Lpetin)及5-羟色胺(5-HT)水平,并比较三组治疗期间的不良反应情况。结果:A组治疗后IELT平均值增加了4.28 min,B组、C组平均增加了1.15及1.22 min,组间比较差异有统计学意义(P0.05),治疗后A组射精控制能力及配偶性生活满意度均较治疗前显著升高,且A组治疗后明显优于B、C组(P0.05),治疗后三组Leptin及5-HT均较治疗前显著改善,且治疗后A组明显优于B、C组,组间比较差异有统计学意义(P0.05)。结论:桂枝加龙骨牡蛎汤应用于治疗心肾不交型早泄能够显著降低血清瘦素并提高5-HT水平,起到良好的治疗效果,且安全性较高。

Effects of Guizhi combined keel oyster decoction on the levels of leptin and 5-HT in patients of premature ejaculation with heart-kidney disharmony type

Objectives:To study the effect of Guizhi combined keel oyster decoction on the levels of leptin and 5-HT in patients of premature ejaculation with heart-kidney disharmony type.Methods:72 patients with heart-kidney disharmony type premature ejaculation in Andrology Department of the People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine were selected and randomly divided into Guizhi combined keel oyster decoction group (group A,24 cases),JinsuoGujing pill group (group B,24 cases) and trazodone group (group C,24 cases).3 groups respectively received different medicine,all for a course of treatment of 4 weeks.The patients were followed up for 4 weeks after drug withdrawal.Compare treatment effect of three groups,the average vagina ejaculation latency (IELT) and premature ejaculation diagnosis scale (PEDT) of three groups before treatment and 8 weeks after treatment were compared.The blood Lpetin and serotonin (5-HT) levels of three groups before and after treatment were compared as well as the situation of adverse reactions during treatment.Results:The average IELT increased by 4.28 min after treatment in group A.Group B and group C increased by 1.15 min and 1.22 min respectively,and the differences among three groups were statistically significant (P ＜ 0.05).The ejaculation control ability and sexual satisfaction in group A had a significant increase after treatment,and group A was obviously better than these in group B and group C (P ＜ 0.05).After treatment,Leptin and 5-HT improved significantly in 3 groups,and group A was better than group B and group C,with statistically significant difference (P ＜ 0.05).Conclusion:Guizhi combined keel oyster decoction in treatment for the premature ejaculation patients with heart-kidney disharmony typecan significantly reduce blood Lpetin and improve the level of 5-HT,with good treatment effect and high safety.