益肾活血方改善肾虚血瘀型不孕症患者子宫内膜容受性临床研究

目的:观察益肾活血方改善肾虚血瘀型不孕症子宫内膜容受性的临床疗效。方法:选择2014年6月至2016年6月于我院不孕不育科门诊就诊的患者60例,采用随机数字表法分为两组各30例,观察组服用益肾活血方,对照组服用戊酸雌二醇。通过B超监测排卵,于排卵后6~8d B超监测子宫内膜情况,计算Salle评分值等进行非劣效研究,评价临床疗效。结果:治疗后分析发现两组患者治疗前后,Salle评分、PI评分与内膜厚度具有统计学差异(P0.05),观察组非劣效于对照组。观察组与对照组受孕率分别为40%(12/30)和20%(6/30),观察组的受孕率明显优于对照组,差异具有统计学意义(P0.05)。结论:益肾活血方可以改善肾虚血瘀型不孕症患者子宫内膜容受性,增加受孕率。

Clinical observation of Yishen Huoxue decoction on improvement of uterine receptivity in patients with kidney deficiency and blood stasis infertility

Objectives:To observe the effect of Yishen Huoxue decoction on improvement of uterine receptivity in patients with kidney deficiency and blood stasis infertility.Methods:A total of 60 patients with kidney deficiency and blood stasis infertility in Xiyuan Hospital Infertility Clinic of China Academy of Traditional Chinese Medicine from June 2015 to June 2016 were randomly divided into 2 groups,with 30 cases in each group.The observation group was treated with Yishen Huoxue decoction and the control group was treated with estradiol valerate.The ovulation was monitored by B ultrasonic examination.The endometrial condition was monitored by B-ultrasound 6-8 days after ovulation and the Salle score was calculated.The non-inferiority study was performed to evaluate the clinical efficacy.Results:After treatment,it was found that there were significant differences in Salle score and PI score between the two groups before and after treatment (P ＜ 0.05).The non-inferiority in observation group was higher than that in control group.The pregnancy rate of observation group and control group was 40％ (12/30) and 20％ (6/30),with statistically significant difference (P ＜ 0.5).Conclusion:Yishen Huoxue decoction can improve the blood stasis in patients with infertility and uterine receptivity,and increase pregnancy rate.