控制性超促排卵下卵巢低反应的预测及妊娠结局的研究

目的：研究控制性超促排卵下卵巢低反应的预测指标及妊娠结局情况。方法：选择拟行IVF／ICSI助孕治疗的152名不孕症女性，根据卵巢反应性分为两组：低反应组（获卵数〈4个）、非低反应组（获卵数≥4个）。收集不孕症女性的相关临床资料进行分析。结果：卵巢低反应的发生率为18．42％（28／152）。两组中年龄、基础FSH值、FSH／LH值、AFC有显著性差异。多因素Logistic回归分析显示：年龄和AFC进入回归模型，年龄与卵巢反应性呈负相关，AFC与卵巢反应性成正相关。周期取消率为19．74％（30／152），卵巢低反应纽（35．71％，10／28）明显高于非低反应组（16．13％，20／124）。移植周期临床妊娠率为51．64％（63／122），卵巢低反应组（22．22％，4／18）明显低于非低反应组（56．73％，59／104）。结论：年龄和AFC可用于卵巢低反应的预测。卵巢低反应可导致周期取消率升高、临床妊娠率降低。

Study of predictive indicators and pregnancy outcome of poor ovarian response in controlled ovarian hyper- stimulation

Objectives： To study the predictive indicators and pregnancy outcome of poor ovarian response in controlled ovarian hyperstimulation. Methods： A total of 152 infertile women undergoing IVF/ICSI were included in this study and divided into 2 groups according to the number of retrieved oocytes ： poor ovarian responders （ 〈 4 oocytes） ; non -poor ovarian responders （ ≥4 oocytes）. Clinical data, including age, duration of infertility, basalfollicle stimulating hormone （FSH） level, antral follicle count （AFC） , total dosages of gonadotropins （Gn） , total number of retrieved oocytes, and clinical pregnancy outcome were obtained. Results： The incidence of poor ovarian response was 18.42% （28/152）. There was significant difference in age, basal FSH, FSH/LH, AFC between poor and non - poor ovarian response. Multi - variate Logistic regression analysis showed a negative correlation be- tween age and ovarian response, and a positive correlation between AFC and ovarian response. In this study, the cy- cle cancellation rate in poor ovarian response （35.71%, 10/28） was higher than that of non - poor response （16. 13% ,20/124）. The clinical pregnancy rate in poor ovarian response （22.22%, 4/18） was lower than that of non -poor response （56.73%, 59/104）. Conclusions： Age and AFC can be used as predictive indicators of poor o- varian response. Poor ovarian response may result in higher cycle cancellation rate and lower clinical pregnancy rate.