乙酰谷酰胺对酒精中毒昏迷患者的急救效果和血清β-EP、氧化应激指标的影响

目的探讨乙酰谷酰胺对酒精中毒昏迷患者的急救效果和血清β内啡肽(β-EP)、氧化应激指标的影响。方法选择2017年1月-2019年3月成都市第三人民医院蒲江医院接诊的115例酒精中毒昏迷患者,通过随机数表法分为观察组60例和对照组55例。两组入院后均给予常规治疗,对照组在此基础上给予盐酸纳洛酮注射液治疗,观察组在对照组基础上,联合乙酰谷酰胺注射液治疗。比较两组临床疗效、临床症状恢复时间、肝功能、血清β-EP、氧化应激指标和清醒后不适症状。结果观察组总有效率明显高于对照组(P<0.05);两组体温正常时间比较差异无统计学意义(P>0.05),观察组苏醒时间、生命体征稳定时间明显短于对照组(P<0.05);治疗后,观察组肝功能指标谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(γ-GT)明显低于对照组(P<0.05);观察组血清β-EP、丙二醛(MDA)明显低于对照组,超氧化物歧化酶(SOD)明显比对照组高(P<0.05);观察组头晕头痛、恶心呕吐、乏力、胸闷发生率均明显低于对照组(P<0.05)。结论在常规治疗基础上,联合乙酰谷酰胺对酒精中毒昏迷患者急救疗效显著,且可有效改善肝功能及血清β-EP、氧化应激指标的表达,减少清醒后不适症状的发生率,值得应用推广。

The first aid effect of acetylglutamide on β-EP and oxidative stress in patients with alcoholism coma

Objective To study the first aid effect of acetylglutamide on β-endorphin(β-EP)and oxidative stress in patients with alcoholism coma.Methods 115 patients of alcoholic coma who received therapy fromjanuary 2017 to March 2019 in our hospital were selected as research objects,according to the random number table,theywere divided into the 60 cases in the observation group and 55 cases in the control group.The 2 groups were given routine treatment after admission,on this basis,the control group was given naloxone hydrochloride injection,the observation group was combined with acetylglutamide injection on the basis of the control group.The clinical efficacy,clinical symptoms recovery time,liver function,serum β-EP,oxidative stress index and discomfort symptoms after awakening were compared between the two groups.Results The total effective rate of the observation group was significantly higher than those in the control group(P<0.05);there was no significant difference in the normal time of body temperature between the two groups(P>0.05),the recovery time and vital signs stabilization time in the observation group were significantly shorter than those in the control group(P<0.05);after treatment,the liver function indexes aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamyltransferase(γ-GT)in the observation group were significantly lower than those in the control group(P<0.05);the serum levels of β-EP and malondialdehyde(MDA)in the observation group were significantly lower than those in the control group,and superoxide dismutase(SOD)was significantly higher than those in the control group(P<0.05);the incidence of dizziness,headache,nausea,vomiting,fatigue and chest tightness in the observation group were significantly lower than those in the control group(P<0.05).Conclusion On the basis of routine treatment,combined acetylglutamide can effectively improve the liver function and the expression of serum β-EP and oxidative stress index,reduce the incidence of discomfort symptoms after awakening,it's worthy of application and promotion.