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Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression
Authors:Donna M. Brennan-Crispi  Andrew M. Overmiller  Lukas Tamayo-Orrego  Molly R. Marous  Joya Sahu  Kathleen P. McGuinn  Felicia Cooper  Ioanna Ch. Georgiou  Maxwell Frankfurter  Julio C. Salas-Alanis  Frédéric Charron  Sarah E. Millar  Mỹ G. Mahoney  Natalia A. Riobo-Del Galdo
Affiliation:1. Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA;2. Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA;3. Sydney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA;4. Biochemistry and Pharmacology Graduate Program, Thomas Jefferson University, Philadelphia, Pennsylvania, USA;5. Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM) Montreal, Quebec, Canada;6. Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada;7. Leeds Institute of Cancer and Pathology, University of Leeds, UK;8. School of Molecular and Cellular Biology, University of Leeds, United Kingdom;9. Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA;10. Center for Molecular Diagnostics and Personalized Medicine, University of Monterrey, Mexico;11. Department of Biology, Department of Anatomy and Cell Biology, and Department of Medicine, McGill University, Montreal, Quebec, Canada;12. Department of Medicine, University of Montreal, Montreal, Quebec, Canada
Abstract:
Keywords:BCC  basal cell carcinoma  Hh  hedgehog  LOH  loss of heterozygosity  p-  phosphorylated  Shh  sonic hedgehog  X-gal  WT  wild type
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