博来霉素瘤体内注射与外用治疗浅表型婴幼儿血管瘤的疗效比较

目的：比较瘤体内注射与外用博来霉素治疗浅表型婴幼儿血管瘤的疗效。方法： 选取2018年12月至2019年12月我院小儿矫形外科住院浅表型血管瘤患儿，随机分成两组，分别予以博来霉素瘤体内注射治疗与瘤体表面外涂治疗。结果：共收集40例浅表型婴幼儿血管瘤，注射组与外用组各20例。外用组显效12例，有效8例，注射组显效14例，有效6例，两组疗效差异无统计学意义（P>0.05）。注射组治疗后瘤体质地硬，而外用组治疗后瘤体质地软；注射组主要不良反应为瘤体局部坏死或感染（P<0.05），外用组未见明显不良反应。结论：外用博来霉素治疗浅表型婴幼儿血管瘤疗效确切，治疗后不良反应少。

Efficacy comparation of intratumoral injection of bleomycin and topical application in the treatment of superficial infantile hemangioma

Objective: To compare the efficacy of intratumoral injection of bleomycin and topical application in the treatment of superficial infantile hemangioma. Methods: The patients with  superficial hemangioma from the pediatric orthopedic surgery in our hospital from December 2018 to December 2019 were collected. The patients were divided into bleomycin injection group and topical application group. Results: A total of 40 patients were collected, 20 in each group. Twelve patients had apparent results and 8 had effective results in the topical application group. Fourteen patients had apparent results and 6 had effective results in the injection group. There was no significant difference of efficacy between the two group (P>0.05), but the tumor became hard in the bleomycin injection group after treatment and which became soft in the topical application group. The common adverse reaction in the injection group was local necrosis or infection. Conclusion: Topical application of bleomycin in the treatment of superficial infantile hemangioma is effective and has less adverse reactions.