血清可溶性白介素2受体检测及其在梅毒中的临床意义

目的：探讨SIL－2R在梅毒血清中的临床意义。方法：采用ELISA抗体夹心法检测75例梅毒患者治疗前后SIL－2R水平、RPR滴度变化及其与各期梅毒临床之间关系。结果：所有梅素血清中SIL－2水平明显高于正常人（P＜0.001）、二期和潜伏期都高于一期（P＜0.01），二期与潜伏期相比无明显差异（P＞0.01）。治疗后各期梅RPR滴度下降，SIL－2R水平也显著下降（P＜0.001），二期，潜伏期梅毒血SIL－2R仍高于对照组（P＜0.05。结论：对同一病例作连续SIL－2R水平检测有助于了解疾病活动性和治疗效果。

Determination of serum SIL-2R level and its clinical significance in syphilitic patients

Objective:To determine the serum SIL-2R level and its clinical significance in syphilitic patients. Methods:The serum SIL-2R level and RPR change before and after benzylpenicillin therapy in patients with syphilis were determined with polyclonal antibody sandwich ELISA. The correlation of serum SIL-2R level with different stages of syphilis was analyzed.Results: The serum SIL-2R level was higher in all stages of syphilis than that in control group (P<0.001) and was higher in both secondary and latent syphilis than that in primary syphilis (P< 0.01 ). There was no significant difference in serum SIL-2R level between secondary and latent syphilis (P> 0.05 ). The titer of serum SIL-2R and RPR decreased in all stages of syphilis after effective treatment. Compared with control group, the serum SIL-2R level in secondary and latent syphilis was still higher (P< 0.05 ). Conclusion :The continual dynamic monitoring of SIL 2R level for the same patient could be used for evaluating the activity of illness and the therapeutic effect.