大疱性系统性红斑狼疮临床资料分析

分析国内近20年发表的大疱性系统性红斑狼疮38篇文献,共57例,其中女47例,男10例,平均(26.6±11.8)岁;典型皮损为暗红色斑疹或正常皮肤上出现水疱大疱;常累及血液系统(64.9%)、肾脏(61.4%)及关节(57.9%);ANA阳性率为100%、dsDNA阳性率为66.7%、Sm抗体阳性率为59.6%;89.1%患者症状得到控制,其中23.6%患者单用糖皮质激素有效,76.4%患者联用DDS或其他免疫抑制剂。

Clinical analysis of bullous systemic lupus erythematosus

Fifty-seven patients (47 females, 10 males) with bullous systemic lupus erythematosus in 38 reports were analyzed.  The average age was (26.6±11.8) years. The typical lesions were tense vesicles and bullae on both erythematous patches and normal skin. 64.9%, 61.4% and 40% patients had hematologic abnormalities, renal involvement and polyarthritis respectively. ANA, dsDNA and anti-Smantibodies were positive in 100%, 66.7%, 59.6% patients respectively. 89.1% patients achieved clinical improvements, of whom 23.6% treated with corticosteroid alone and 76.4% treated with corticosteroid and DDS or other immunosuppressants.