| 非桥粒芯糖蛋白抗体在寻常型天疱疮中的作用机制 |
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| 引用本文： | 谢志敏,沈旭成,戴向农,李青青,叶兴东.非桥粒芯糖蛋白抗体在寻常型天疱疮中的作用机制[J].中国麻风皮肤病杂志,2021,37(5):324-327. |
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| 作者姓名： | 谢志敏 沈旭成 戴向农 李青青 叶兴东 |
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| 作者单位： | 1广州市皮肤病防治所皮肤科，广州，510095；
2广州医科大学皮肤病研究所皮肤科，广州，510095 |
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| 摘 要： | 既往发现寻常型天疱疮（pemphigus vulgaris, PV）发病机制与桥粒芯糖蛋白1（desmoglein，Dsg1)和 Dsg3抗体有关，目前在PV患者中发现大量非Dsg自身免疫性抗体，包括桥粒胶蛋白1（desmocollin，Dsc1）和Dsc3、斑菲素蛋白1（plakophilin，PKP1）和PKP3、斑珠蛋白（plakoglobin，PG）、桥粒斑蛋白（desmoplakin，DP）、乙酰胆碱受体等。本文对非Dsg蛋白在PV发病机制中的作用进行了综述。
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| 关 键 词： | 寻常型天疱疮 桥粒胶蛋白 斑菲素蛋白 乙酰胆碱受体 甲状腺过氧化物酶 |
Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris |
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| XIE Zhimin,SHEN Xuchen,DAI Xiangnong,LI Qingqing,YE Xingdong.Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris[J].China Journal of Leprosy and Skin Diseases,2021,37(5):324-327. |
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| Authors: | XIE Zhimin SHEN Xuchen DAI Xiangnong LI Qingqing YE Xingdong |
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| Institution: | 1 Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China; 2 Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China |
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| Abstract: | The the pathogenesis of pemphigus vulgaris (PV) was associated with autoantibodies against desmosomal cadherin, desmoglein1 (Dsg1) and Dsg3 in previous studies, and now many non-Dsg autoantibodies were reported including desmocollin (Dsc) 1 and Dsc3, plakophilin (PKP) 1 and PKP3, plakoglobin (PG), desmoplakin (DP), acetylcholine receptor (AChR), secretory pathway Ca2+/Mn2+-ATPase isoform 1 (SPCA1), thyroid peroxidase (TPO) and mitochondrial protein. The non-Dsg autoantibodies associated with pathogenesis of PV were reviewed in this paper. |
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| Keywords: | pemphigus vulgaris desmocollin plakophilin acetylcholine receptor thyroid peroxidase |
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