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Evaluating change in disease activity needed to reflect meaningful improvement in quality of life for clinical trials in cutaneous lupus erythematosus

Authors:	Srita Chakka Rebecca L Krain Sarah Ahmed Josef Symon S Concha Rui Feng Joan T Merrill Victoria P Werth

Institution:	1. Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania;2. Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania;3. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania;4. Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma

Abstract:

Keywords:	autoimmune skin disease clinical trials cutaneous lupus erythematosus efficacy measures patient-reported outcomes quality of life CLASI"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"Cutaneous Lupus Disease Area and Severity Index CLASI-A"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"Cutaneous Lupus Disease Area and Severity Index activity score CLE"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"cutaneous lupus erythematosus DLQI"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"Dermatology Life Quality Index DM"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"dermatomyositis QoL"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"quality of life Skindex-E"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"Emotions subscale of Skindex-29 Skindex-F"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"Functioning subscale of Skindex-29 Skindex-S"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"Symptoms subscale of Skindex-29 SLE"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"systemic lupus erythematosus
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