IL-17 and its role in inflammatory,autoimmune, and oncological skin diseases: state of art |
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| Authors: | Nicoletta Bernardini PhD Nevena Skroza MD Ersilia Tolino MD Alessandra Mambrin MD Alessia Anzalone MD Veronica Balduzzi MD Daniela Colapietra MD Anna Marchesiello MD Simone Michelini MD Ilaria Proietti PhD Concetta Potenza MD |
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| Institution: | Dermatology Unit “Daniele Innocenzi”, Department of Medico-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Teracina, Italy |
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| Abstract: | Recent data support the theory of the involvement of IL-17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL-17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL-17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers. |
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