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| 外阴阴道念珠菌病患者阴道分泌物IL-12和IL-23的检测 | |
| 引用本文： | 夏毓,喻楠,何秉洁,李义德,王琪,尚元元,杨占录.外阴阴道念珠菌病患者阴道分泌物IL-12和IL-23的检测[J].中国皮肤性病学杂志,2010,24(2). |
| 作者姓名： | 夏毓 喻楠 何秉洁 李义德 王琪 尚元元 杨占录 |
| 作者单位： | 1. 宁夏医科大学,宁夏,银川,750004 2. 宁夏医科大学附属医院皮肤科,宁夏,银川,750004 3. 宁夏医科大学附属医院妇科,宁夏,银川,750004 4. 宁夏医科大学附属医院医学实验中心,宁夏,银川,750004 |
| 基金项目： | 宁夏自治区卫生厅重点科研计划项目，杨森科学研究基金 |
| 摘 要： | 目的探讨细胞因子IL-12和IL-23的表达水平与不同严重程度外阴阴道念珠菌病发病的关系。方法ELISA法检测轻中度、重度各组外阴阴道念珠菌病及复发性外阴阴道念珠菌病(RVVC)患者阴道分泌物中IL-12p70和IL-23p19的表达水平,以正常女性白念珠菌携带者为对照组。结果各组外阴阴道念珠菌病患者的IL-12p70和IL-23p19表达水平均低于对照组,且各组间比较差异均有显著性(F=13.486,P=0.000:F=11.869,P=0.000);组间两两比较,重度外阴阴道念珠菌病组和RVVC组IL-12p70的水平均低于对照组,差异有显著性(t=2.243,P=0.035;t=3.397,P=0.000);RVVC组IL-23p19的水平低于对照组,差异有显著性(t=3.289,P=0.000)。结论IL-12和IL-23的表达异常可能与外阴阴道念珠菌病的发病、病情严重程度和复发有关。 |
| 关 键 词： | 白细胞介素-12 白细胞介素-23 外阴阴道念珠菌病 |
The Vaginal Secretion of IL-12 and IL-23 and Its Significance in Varying Degrees of Serious Vulvovaginal Candidiasis Patients |
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| XIA Yu,YU Nan,HE Bing-jie,LI Yi-de,WANG Qi,SHANG Yuan-yuan,YANG Zhan-lu.The Vaginal Secretion of IL-12 and IL-23 and Its Significance in Varying Degrees of Serious Vulvovaginal Candidiasis Patients[J].The Chinese Journal of Dermatovenereology,2010,24(2). | |
| Authors: | XIA Yu YU Nan HE Bing-jie LI Yi-de WANG Qi SHANG Yuan-yuan YANG Zhan-lu |
| Institution: | XIA Yu1,YU Nan2,HE Bing-jie3,LI Yi-de4,WANG Qi2,SHANG Yuan-yuan2,YANG Zhan-lu1(1.Ningxia Medical University,Yinchuan 750004,China,2.Department of Dermatology,Affiliate Hospital of Ningxia Medical University,3.Department of Gynecology,4.Department of Medical Experiment,China) |
| Abstract: | Objective To detect the secretion level of interleukin-12(IL-12) and interleukin-23(IL-23) in the vaginal of vulvovaginal candidiasis patients and to investigate their relationship with the pathogenesis of varying degree of vulvovaginal candidiasis.Methods The level of the IL-12p70 and IL-23p19 in the vaginal secretion from vulvovaginal candidiasis patients were detected by ELISA and compared with that from normal controls.Results The vaginal secretion level of IL-12 p70 and IL-23p19 in varying degree of se... |
| Keywords: | Interleukin-12 Interleukin-23 Vulvovaginal candidiasis |
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