8种抗菌药物体外抗解脲支原体与人型支原体的活性研究

目的指导临床合理用药。方法采用肉汤稀释方法，测定８种抗菌药物对２０株解脲支原体（ＵＵ）、２０株人型支原体（ＭＨ）体外抗菌作用效果。结果交沙霉素有较强的抗ＵＵ与ＭＨ作用。其ＭＩＣ５０与ＭＩＣ９０为０．２５～２ｍｇ／Ｌ和０．１２５～０．５ｍｇ／Ｌ。强力霉素抗ＵＵ的ＭＩＣ５０与ＭＩＣ９０为４ｍｇ／Ｌ与３２ｍｇ／Ｌ，抗ＭＨ为２ｍｇ／Ｌ和４ｍｇ／Ｌ。氧氟沙星抗ＵＵ的ＭＩＣ５０与ＭＩＣ９０为８ｍｇ／Ｌ与１６ｍｇ／Ｌ，抗ＭＨ为２ｍｇ／Ｌ和４ｍｇ／Ｌ。ＭＨ对罗红霉素与阿奇红霉素有高度抵抗作用，ＭＩＣ５０与ＭＩＣ９０为６４ｍｇ／Ｌ与１２８ｍｇ／Ｌ。５株ＵＵ、４株ＭＨ对四环素高度耐药，其ＭＩＣ５０与ＭＩＣ９０为６４ｍｇ／Ｌ与１２８ｍｇ／Ｌ和３２ｍｇ／Ｌ与６４ｍｇ／Ｌ，对强力霉素与美满霉素也呈高度抵抗，ＭＩＣ９０为１６～３２ｍｇ／Ｌ，但对氧氟沙星较为敏感，ＭＩＣ９０为４ｍｇ／Ｌ。结论本研究提示ＭＨ的耐药性检测，对指导临床治疗具有重要意义。

Antibacterial Activities of 8 Antimicrobial Agents Against Ureaplasma Urealyticum and Mycoplasma Hominis In vitro.

Objective In order to instrust rational application of antibiotics clinically.Methods Antibacterial activities of 8 antimicrobial agents against 20 strains of Ureaplasma Urealyticum (UU),20 strains of Mycoplasma hominis (MH) were determined using the broth dilution.Results Jasamycin was highly active against UU and MH for UU MIC 50 was 0.25mg/L and MIC 90 2mg/L,and for MH MIC 50 was 0.125mg/L and MIC 90 0.5mg/L,Doxycycline was active against UU(MIC 50 to MIC 90 ,4 to 32mg/L),whereas the MIC 50 to MIC 90 for MH was 2 to 4mg/L.Ofloxacin was active against UU,MIC 90 for MH was 2 to 4mg/L.ofloxacin was active against UU,MIC 50 8mg/L and MIC 90 16mg/L against MH,MIC 50 2mg/L and MIC 90 4mg/L.MH was higly resistant to roxithromycin and azithromycin(MIC 50 64mg/L and MIC 90 128mg/L).Five strains of UU and 4 strains of MH ware higly resistant to tetracycline (MIC 50 64 and 32mg/L,MIC 90 128 and 64mg/L)and yet still resistant to doxycycline and minocycline (MIC 90 16 to 32mg/L),but sensitive to ofloxacin (MIC 90 4mg/L).Conclusion The results suggested that resistant determination of MH important significance to clinical drug treatment.