泛发性带状疱疹中文文献meta分析

目的:汇总我国报告的泛发性带状疱疹(HZG)病例资料数据,分析可能影响HZG治疗结局及预后的危险因素。方法:检索中国生物医学文献数据库和中国期刊全文数据库,筛选合格文献,提取数据。用SPSS 10.0进行统计学分析。结果:入选文献84篇,共报告HZG 111例,以60-70岁发病者最多(21.6%);88例(79.3%)痊愈,15例(13.5%)出现并发症,8例(7.2%)死亡。回归分析显示,发病至起始治疗的时间、首发部位、是否伴有基础疾病进入模型,与HZG结局显著相关。结论:HZG发病至起始治疗的时间、首发部位、是否伴有基础疾病可能影响治疗的结局及预后。

Herpes Zoster Generalisatus: A Meta-analysis of Individual Patient Data Reported in China

Objective:To analyze the profiles of herpes zoster generalisatus(HZG) reported in China and identify risk factors underlying serious terminations of the disease. Methods:A search in document databases for HZG cases was conducted to summarize the characteristics of HZG in China by meta-analysis using Excel and SPSS software.Results: Eighty-four papers entered the meta-analysis in which 111 HZG cases were reported from 25 provinces in China.The highest onset interval(21.6%) appeared in 60-70 years old.Sixty-three percent HZG cases had some systemic disease and 7.2% cases dead.Logistic regression model showed that the aftermath of HZG was associated with the time to beginning treatment,the start onset site,and concomitant systemic diseases.Conclusion:The time to begin treatment,the start onset site,and concomitant systemic diseases probably have an effect on the eventual outcomes of HZG.