Neutralizing antibody responses to SARS-CoV-2: A population based seroepidemiological analysis |
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Institution: | 1. Department of Community Medicine, Maulana Azad Medical College, New Delhi, India;2. Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India;3. Indian Institute of Public Health – Delhi, Public Health Foundation of India, New Delhi, India;4. Directorate General Health Services, Government of NCT, New Delhi, India |
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Abstract: | This study (August–September 2021) estimated the seroprevalence of SARS-CoV-2 neutralizing antibodies in the general population of Delhi and correlated it with their anti-SARS-CoV-2 IgG levels. Samples were selected by simple random sampling method. The neutralizing capacity was estimated by performing a surrogate virus neutralization test (sVNT) (GenScript), Piscataway, NJ, USA.A total of 2233 (87.1%, 95% C.I. 85.7, 88.3) of the 2564 SARS-CoV-2 IgG seropositive samples had detectable SARS-CoV-2 neutralizing antibodies. In samples with S/CO ?≥ ?4.00, the neutralizing antibodies ranged from 94.5% to 100%. The SARS-CoV-2 neutralizing antibody seroprevalence strongly correlated with the S/CO range of IgG SARS-CoV-2 (r ?= ?0.62, p ?= ?0.002). |
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Keywords: | SARS-CoV-2 Anti-SARS-CoV-2 neutralizing antibody Vaccination Covid-19 |
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