A systematic review and meta-analysis on the antibiotic resistance of Neisseria meningitidis in the last 20 years in the world |
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| Authors: | Mosayeb Rostamian Roya Chegene Lorestani Somayeh Jafari Rezvan Mansouri Shahab Rezaeian Keyghobad Ghadiri Alisha Akya |
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| Institution: | 1. Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Student Research Committee and Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran;1. Department of Clinical Microbiology and Infectious Diseases, All India Institute of Medical Sciences, Mangalagiri (AP), India;2. Department of Paediatric Gastroenterology, Post Graduate Institute of Child Health, NOIDA, India;3. Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India;4. Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India;1. Department of Clinical Laboratory, Liaocheng People''s Hospital, No. 67, Dongchangxi Road, Dongchangfu District, Liaocheng 252000, Shandong Province, People''s Republic of China;2. Department Hepatobiliary Surgery, Liaocheng People''s Hospital, No. 67, Dongchangxi Road, Dongchangfu District, Liaocheng 252000, Shandong Province, People''s Republic of China;3. Department Pediatrics, Liaocheng People''s Hospital, No. 67, Dongchangxi Road, Dongchangfu District, Liaocheng 252000, Shandong Province, People''s Republic of China;1. Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India;2. Department of Microbiology, GIPMER, Delhi, India;1. Infectious Diseases, Rajiv Gandhi Cancer Institute, New Delhi, India;2. Microbiology, Rajiv Gandhi Cancer Institute, New Delhi, India;3. Hematology, Rajiv Gandhi Cancer Institute, New Delhi, India;4. Medical Oncology, Rajiv Gandhi Cancer Institute, New Delhi, India;1. Department of Microbiology, Jawaharlal Nehru Medical College & Hospital, Ajmer (Rajasthan), India;2. Department of Medical Microbiology, Postgraduate Institution of Medical Education & Research (PGIMER), Chandigarh, India;3. Department of Microbiology, Govt. Medical College & Hospital, Chandigarh, India;4. Department of Microbiology, Shri Ramachandra Institute of Higher Education & Research Institute, Chennai, India |
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| Abstract: | BackgroundNeisseria meningitidis is one of the most important causes of meningitis and pathogens-associated deaths in developing and developed countries. Effective anti-microbial agents are pivotal to treat and control N. meningitidis infections. The aim of the present study was to systematically review published studies on the antibiotic resistance of N. meningitidis in the last 20 years (2000–2020) in the world.MethodsPublished researches were identified through a literature search using reputable databases including PubMed, Scopus, and Web of Science. Finally, 24 studies were included for a random-effects model meta-analysis.ResultsThe overall resistance to most commonly used antibiotics such as ceftriaxone, cefotaxime, ciprofloxacin and rifampin was low, ranging from 1 to 3.4%. However, non-sensitivity to penicillin, as the first-line antibiotic against N. meningitidis, was higher (27.2%). Altogether, the resistance to the first-line antibiotics (except penicillin) is still low indicating these drugs are effective against meningococcal meningitis. We also found a significant gap between MIC and disk diffusion for evaluating resistance to antibiotics in which disk diffusion overestimate the resistance rate.ConclusionsTo properly management and prevent the spread of N. miningitidis isolates resistant antibiotics, it is necessary to monitor the pattern of antibiotic susceptibility regionally and globally using the MIC methods. |
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| Keywords: | Antibiotic resistance Meningitis Meta-analysis Systematic review |
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