曲唑酮对治疗脑卒中后抑郁患者睡眠障碍的临床观察

目的探讨曲唑酮治疗脑卒中后抑郁患者睡眠障碍的疗效。方法将脑卒中后抑郁并出现睡眠障碍的患者60例随机分为曲唑酮治疗组和对照组各30名,治疗前,治疗后4、6周分别给予匹兹堡睡眠指数量表(PSQI)及汉密尔顿抑郁量表(HAMD)评分。结果治疗前两组两个量表得分差异无统计学意义,治疗后4周及治疗后6周得分差异均有统计学意义。治疗4周(PSQI:t=5.577,P0.01;HAMD:t=4.917,P0.01),治疗6周后(PSQI:t=7.007,P0.01;HAMD:t=7.888,P0.01),治疗组睡眠质量明显改善,且明显高于对照组(P0.01),曲唑酮治疗组抑郁状态改善明显优于对照组(P0.01)。结论曲唑酮可有效改善脑卒中后抑郁患者睡眠障碍。

Clinical Observation of Trazodone in the Treatment of Sleep Disorder of Patients with Depression after Stroke

Objective To investigate the clinical effect of trazodone in the treatment of sleep disorders of patients with depression af -ter stroke.Methods A total of 60 patients of poststroke depression with somnipathy were randomly divided into trazodone group （n=30） and control group（n=30）,and assessed with Pittsburgh sleep quality index scale and HAMD before treatment ,4 weeks and 6 weeks after treatment respectively .Results There were no significant differences in sleep quality and HAMD scores between two groups before treat -ment.But they had significant differences in 4 weeks and 6 weeks after treatment（PSQI：t=5.577,7.007;P＜0.01;HAMD：t=4.917, 7.888;P＜0.01）,sleep quality improved significantly in the treatment group ,and was significantly higher than that in the control group;Depression was improved in trazodone group ,and was obviously higher than that of control group （P＜0.01）.Conclusion Trazodone can effectively improve sleep disorders in patients with depression after stroke.