促血管生成因子对糖尿病足作用机制的研究进展

糖尿病足是继发于糖尿病终末期的下肢溃疡缺血性疾病。促血管生成因子在糖尿病下肢缺血性疾病中的作用机制十分复杂，不同促血管生成因子发挥的作用不尽相同。在缺血损伤区域的修复过程中，促血管生成因子的表达上升，参与组织缺血损伤区血管结构的重建，改善局部血液循环，使组织缺血损伤得到修复。病理情况下，促血管生成因子参与炎症级联反应，与缺血/再灌注损伤关系密切，还可能诱导硬化斑块破裂、增加能量的代谢消耗，产生不利影响。近年来，随着再生医学研究的深入，促血管生成因子开始应用于糖尿病足的治疗中，逐渐成为糖尿病足新的治疗靶点。

Advances in Research on the Mechanism of Pro-angiogenic Factors on Diabetic Foot

Diabetic foot is an ischemic disease of the lower extremity ulcer secondary to the end stage of diabetes.The mechanism of action of angiogenic factors in diabetic lower limb ischemic diseases is very complex,and different pro-angiogenic factors play different roles.During the repair of ischemic injury,the expression of pro-angiogenic factors increases,participates in the reconstruction of vascular structures in the ischemic injury area,improves local blood circulation,and repairs tissue ischemic injury.In pathological conditions,pro-angiogenic factors are involved in the inflammatory cascade,which is closely related to ischemia/reperfusion injury.It may also induce plaque rupture,increase energy metabolism,and have adverse effects.In recent years,with the deepening of regenerative medicine research,pro-angiogenic factors have begun to be used in the treatment of diabetic foot,and have gradually become a new therapeutic target for diabetic foot.