| 胰腺癌微淋巴管的分布及其临床意义 |
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| 引用本文： | 张春生,胡安国,张波,李胜.胰腺癌微淋巴管的分布及其临床意义[J].医学信息,2007,20(6):487-490. |
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| 作者姓名： | 张春生 胡安国 张波 李胜 |
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| 作者单位： | 山东中医药大学第二附属医院普外科，山东中医药大学第二附属医院普外科，山东省肿瘤医院肝胆外科，山东省肿瘤医院肝胆外科 济南250001，济南250001 |
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| 基金项目： | 国家自然科学基金(30571712)，山东省优秀中青年科学家科研奖励基金(2005BS03003)，山东省卫生厅项目(2005-169)资助 |
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| 摘 要： | 目的探讨胰腺癌组织周边和内部VEGF-C、VEGF-D蛋白表达与微淋巴管密度(microlymphtic vesseles density,MLVD)及淋巴结转移之间的相关关系,阐明癌周淋巴管增生的机制及意义。方法免疫组化检测30例胰腺癌组织周边和内部VEGF-C、VEGF-D、VEGFR-3(MLVD)蛋白的表达。结果肿瘤周边部位VEGF-C、VEGF-D蛋白阳性率分别为73.3%(22/30)、56.7%(17/30),显著高于肿瘤中心部位;在VEGF-C蛋白阳性组,MLVD显著高于阴性组(P<0.01),淋巴结转移发生率增高(P=0.0318);VEGF-D蛋白阳性组MLVD高于阴性组(P<0.01),淋巴结转移发生率增加(P=0.0179)。结论胰腺癌癌周VEGF-C、VEGF-D蛋白表达、MLVD显著高于肿瘤中心部位;癌周VEGF-C、VEGF-D蛋白表达、MLVD与淋巴结转移发生率呈正相关;提示VEGF-C和VEGF-D诱导胰腺癌癌周淋巴管生成,促进肿瘤细胞淋巴道转移。
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| 关 键 词： | 胰腺肿瘤 微淋巴管密度 血管内皮生长因子 淋巴结 |
| 文章编号： | 1006-1959（2007）06-0487-04 |
| 修稿时间： | 2007-04-12 |
The distribution and significance of microlymphatic vesseles in pancreatic cancer |
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| ZHANG Chun - sheng , HU An - guo , ZHANG Bo, et al.The distribution and significance of microlymphatic vesseles in pancreatic cancer[J].Medical Information,2007,20(6):487-490. |
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| Authors: | ZHANG Chun - sheng HU An - guo ZHANG Bo |
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| Institution: | 1. Department of Gengral Surgery, the Sencond Hospital Affiliated of Shandong Traditional Chinese Medicine University, Ji - nan 250001, Shandong Province, China;2. Department of Hepatobiliary Surgery, Shandong Province Tumor Hospital |
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| Abstract: | Objective To investigate the relationship of VEGF-C,VEGF-D and their MLVD,lymph node metastasis in pancreatic cancer,and to explain the mechanism and significance of the cancerous peripheral tissue lymphatic vesseles.Methods The expression of VEGF-C,VEGF-D,MLVD was assayed in and around cancerous tissue by means of immunohistochemistry in 30 pancreatic carcinomas.Results The positive rates of VEGF-C,VEGF-D were 73%(22/30),57%(17/30) respectively in pancreatic cancer.The expression of VEGF-C,VEGF-D around cancerous invasive edge was significantely higher than that in the center of cancerous tissues.The MLVD and positive lymph node metastasis in positive VEGF-C or VEGF-D group were higher than that in the negative group. Conclusions The expression of VEGF-C,VEGF-D around cancerous invasive edge was significantely higher than that in the center of cancerous tissue.There was a positive relationship between the expression of VEGF-C,VEGF-D and their MLVD,lymph node metastasis.VEGF-C and VEGF-D induced lymphangiogenisis in pancreatic cancer,promoted the tumor cell lymph metastasis. |
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| Keywords: | pancreatic tumor MLVD vascular endothelial growth factor lymph node |
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