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Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties
Authors:Yiting Tang  Xiangyu Wang  Zhaozheng Li  Zhihui He  Xinyu Yang  Xiaoye Cheng  Yue Peng  Qianqian Xue  Yang Bai  Rui Zhang  Kai Zhao  Fang Liang  Xianzhong Xiao  Ulf Andersson  Haichao Wang  Timothy R Billiar  Ben Lu
Institution:1. Department of Critical Care Medicine and Hematology, The 3rd Xiangya Hospital, Central South University, Changsha, 410000 P.R. China;2. Department of Physiology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, 410000 P.R. China;3. Department of Pathophysiology, School of Basic Medical Science, Central South University, Changsha, Hunan Province, 410000 P.R. China;4. Key Laboratory of sepsis translational medicine of Hunan, Central South University, Changsha, Hunan Province, 410000 P.R. China;5. Department of Women’s and Children’s Health, Karolinska Institute, 171 76, Stockholm, Sweden;6. The Feinstein Institute for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA;7. Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213 USA
Abstract:
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  • Keywords:Caspase-11  non-canonical inflammasome  heparin  sepsis  coagulation
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