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Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides
Institution:1. Institute for Anatomy and Cell Biology, German Center for Lung Research, Justus Liebig University, 35385 Giessen, Germany;2. Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany;3. Department of Medicine III, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany;4. Center for Integrative Physiology and Molecular Medicine, Saarland University, 66421 Homburg, Germany;5. Institute of Anatomy and Cell Biology, Philipps-University, 35037 Marburg, Germany;6. Institute of Biochemistry, Justus Liebig University, 35385 Giessen, Germany;7. Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University, 66421 Homburg, Germany;8. Institute of Medical Microbiology, German Center for Infection Research, Justus Liebig University, 35385 Giessen, Germany;9. Institute of Hygiene and Infectious Diseases of Animals, Justus Liebig University, 35392 Giessen, Germany;10. Center for Interstitial and Rare Lung Diseases, Department of Internal Medicine, German Center for Lung Research, Justus Liebig University, 35385 Giessen, Germany;11. Agaplesion Lung Clinic Waldhof-Elgershausen, 35753 Greifenstein, Germany;12. Walther-Straub Institute of Pharmacology and Toxicology, German Center for Lung Research, Ludwig-Maximilians-Universität München, 80336 Munich, Germany;13. Institute of Physiology and Pathophysiology, Philipps-University, 35037 Marburg, Germany;14. Department of Pharmacology and Clinical Pharmacy, FB14, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany;15. Laboratory of Cell Calcium Signaling, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210 Shanghai, China;16. Department of Informatics and Microsystems Technology, University of Applied Sciences, 67659 Kaiserslautern, Germany
Abstract:
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  • Keywords:acetylcholine  bitter receptors  brush cells  chemosensory cells  formylated bacterial peptides  formyl peptide receptors  mucociliary clearance  taste transduction  trachea  transient receptor potential cation channel subfamily M member 5  tuft cells
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