| PI3K/Akt/mTOR信号通路及其相关基因突变与子宫内膜癌靶向性药物治疗的研究进展 |
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| 引用本文： | 曹楚楚,黄炉仁,傅芬.PI3K/Akt/mTOR信号通路及其相关基因突变与子宫内膜癌靶向性药物治疗的研究进展[J].基础医学与临床,2017,37(1). |
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| 作者姓名： | 曹楚楚 黄炉仁 傅芬 |
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| 作者单位： | 南昌大学第二附属医院妇产科,江西南昌,330006 |
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| 摘 要： | 子宫内膜癌(EC)是最常见的女性生殖道恶性肿瘤之一,其发生发展的分子生物学机制十分复杂。近年来研究发现,磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路调节异常与子宫内膜癌密切相关。PI3K/Akt/mTOR信号通路中的多种受体及激酶的突变和异常激活,可能成为子宫内膜癌治疗的靶点。
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| 关 键 词： | PI3K/Akt/mTOR信号通路 基因突变 子宫内膜癌 靶向治疗 |
Research advances of PI 3 K/Akt/mTOR signaling pathway with its related gene mutations and the targeted therapy for endometrial cancer |
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| CAO Chu-chu,HUANG Lu-ren,FU Fen.Research advances of PI 3 K/Akt/mTOR signaling pathway with its related gene mutations and the targeted therapy for endometrial cancer[J].Basic Medical Sciences and Clinics,2017,37(1). |
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| Authors: | CAO Chu-chu HUANG Lu-ren FU Fen |
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| Abstract: | Endometrial cancer ( EC) is one of the most common gynecological cancer ,of which the molecular biolog-ical mechanisms is very complex .In recent years, it has been reported that the abnormally regulated PI 3K/Akt/mTOR signaling pathway is significantly related with endometrial cancer .The mutation and abnormal activation of the receptors and kinase of the PI 3 K/Akt/mTOR signaling pathway is a potential therapeutic target of endometrial cancer . |
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| Keywords: | the PI3K/Akt/mTOR signaling pathway gene mutations endometrial cancer targeted therapy |
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