Unusually rapid development of a HBsAG-positive liver cirrhosis after liver transplantation

Summary We report the case of a 44-year-old man who was transplanted in 1986 for hepatocellular carcinoma in a HBsAG-positive liver cirrhosis. The patient had no severe complications postoperatively. He received passive immunization for the prevention of hepatitis B reinfection during the first 6 months after liver grafting. Twelve months after the transplantation the new liver was reinfected with hepatitis B virus. Without any clinical or laboratory signs of severe hepatitis, the patient developed a histologically proven complete liver cirrhosis within 8 months after reinfection of the graft. The reasons for this might have been, first, a deleterious course of the infection under immunosuppressive therapy, and, second, the additional influence of a postoperatively acquired CMV infection or the combined toxic influence of cyclosporin A and its metabolites on the acute inflammation in the liver.Abbreviations ALT Alanine aminotransferase (EC No 2.6.1.2) - AST Aspartate aminotransferase (EC No 2.6.1.1) - CMV Cytomegalo virus - EBV Ebstein-Barr virus - ELISA Enzyme linked immunosorbentassay - HBV Hepatitis B virus - HLA Human leukocyte antigen - HSV Herpes simplex virus