Ultra-deep sequencing provides insights into the virology of hepatitis C super-infections in a case of three sequential infections with different genotypes |
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| Institution: | 1. Laboratoire de Biologie Moléculaire et Immunologie (BIOLIM/FSS/UL), Faculté des Sciences de la Santé, Université de Lomé, Togo;2. UMI 233, Institut de Recherche pour le Développement (IRD), INSERM U1175 and Université de Montpellier, Montpellier, France;3. Association Arc-en-Ciel, Lomé, Togo;4. Programme National de Lutte contre le Sida et les IST/Togo (PNLS/IST/Togo), Lomé, Togo;5. Université de Lomé, Département de Santé Publique, Lomé, Togo;6. Université de Bordeaux, ISPED, Centre INSERM U1219-Epidemiologie-Biostatistique, F-33000 Bordeaux, France;7. Conseil National de Lutte contre le SIDA (CNLS) et Faculté des Sciences de la Santé, Lomé, Togo |
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| Abstract: | The current epidemic of Hepatitis C infection in HIV-positive men who have sex with men is associated with increasing use of recreational drugs. Multiple HCV infections have been reported in haemophiliacs and intravenous drug users. Using ultra-deep sequencing analysis, we present the case of an HIV-positive MSM with evidence of three sequential HCV infections, each occurring during the acute phase of the preceding infection, following risk exposures. We observed rapid replacement of the original strain by the incoming genotype at subsequent time points. The impact of HCV super-infection remains unclear and UDS may provide new insights. |
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| Keywords: | Hepatitis C HIV Ultra-deep sequencing Super-infection Genotype |
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