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分枝杆菌多糖免疫调节作用的研究
引用本文:陈仁,赵文明.分枝杆菌多糖免疫调节作用的研究[J].中华微生物学和免疫学杂志,1995,15(5):328-331.
作者姓名:陈仁  赵文明
作者单位:首都医科大学免疫学研究室,首都医科大学免疫学研究室,首都医科大学免疫学研究室,北京市友谊医院临床医学研究所免疫室,中日友好医院临床医学研究所病理生理研究室,中国医学科学院肿瘤研究所免疫室 100054 北京,100054 北京,100054 北京
摘    要:由非致病性分枝杆菌中提取出的多糖成分,命名为分枝杆菌多糖,动物实验表明,MPS可增强小鼠巨噬细胞的吞噬杀伤活性;提高小鼠产生抗SRbc抗体能力;促进经环磷酰胺处理小鼠减少的白细胞迅速回升;回强小鼠造血祖细胞功能及提高其血清GM-CSF水平。

关 键 词:分枝杆菌多糖  免疫调节  促造血功能作用

THE IMMUNOREGULATORY FUNCTION OF MYCOBACTERIAL POLYSACCHARIDES
Chen Ren,Zhao Wenming,Shen Haizhong,et al.THE IMMUNOREGULATORY FUNCTION OF MYCOBACTERIAL POLYSACCHARIDES[J].Chinese Journal of Microbiology and Immunology,1995,15(5):328-331.
Authors:Chen Ren  Zhao Wenming  Shen Haizhong  
Institution:Chen Ren,Zhao Wenming,Shen Haizhong,et al Department of Immunology Capital University of Medical Sciences,Beijing 100054
Abstract:Polysaccharides extracted from non-pathogenic Mycobacteria,was named Mycobacterial polysaccharides(MPS). In experimental animals it was proved that MPS could increase the phagocytic and killing activity of peritoneal macrophages in mouse,enhance the production of anti-SRbc antibodies,increase the WBC count,which was inhibited by cyclophosphamide,strengthen the function of hemopoitic stem cells and the GM-CSF in sera of mice raised obviously.In the healthy volunteers,MPS could enhance the cytotoxic activity of NK cells. In the presence of suboptimum dose (40U/ml) of IL-2,MPS could strengthen the activity of LAK cells and induce the production of IL-2 from mononuclear cells in vitro.All these results indicated that MPS not only enhanced the cell mediated immunity,but also strengthened the hemopoietic function obviously.
Keywords:Mycobacterial polysaccharides i Immunoregulation  Hemopoietic function
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