Integration from proteins to organs: the IUPS Physiome Project |
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Authors: | Hunter Peter Smith Nicolas Fernandez Justin Tawhai Merryn |
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Affiliation: | Bioengineering Institute, University of Auckland, 70 Symonds Street, Auckland, New Zealand. p.hunter@auckland.ac.nz |
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Abstract: | The IUPS Physiome Project is an internationally collaborative open source project intended to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales and across all organ systems. Here, we illustrate the application of this multi-scale modeling approach to three organ systems: the heart, the lungs and the musculo-skeletal system, and in each case we show how the organ level models incorporate tissue and cell-level physiology. Although the computational physiology framework presented here does not yet incorporate models of ageing processes, the model-based approach is certainly capable of describing ageing and disease-related processes both via parameter changes within the models of normal physiological processes and via models of additional processes added to the framework. |
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Keywords: | Physiome Project Computational physiology Multi-scale modeling Conservation laws |
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