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Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation |
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| Authors: | Sakaguchi Takemasa Irie Takashi Kawabata Ryoko Yoshida Asuka Maruyama Hirofumi Kawakami Hideshi |
| Institution: | aDepartment of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan;bDepartment of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan |
| Abstract: | |
| Keywords: | Abbreviations: ALS amyotrophic lateral sclerosis IFN interferon IRF3 interferon regulatory factor-3 ISRE interferon-stimulated response element MDA5 melanoma differentiation-associated gene 5 TBK-1 TANK-binding kinase-1 TLR3 Toll-like receptor 3 TRAF6 TNF receptor-associated factor 6 TRIF Toll-IL-1 receptor domain-containing adaptor-inducing interferon-β |
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