Biomedical applications of photoacoustic imaging with exogenous contrast agents |
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Authors: | Luke Geoffrey P Yeager Doug Emelianov Stanislav Y |
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Institution: | (1) The University of Texas at Austin, Austin, TX, USA; |
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Abstract: | Photoacoustic imaging is a biomedical imaging modality that provides functional information, and, with the help of exogenous
contrast agents, cellular and molecular signatures of tissue. In this article, we review the biomedical applications of photoacoustic
imaging assisted with exogenous contrast agents. Dyes, noble metal nanoparticles, and other constructs are contrast agents
which absorb strongly in the near-infrared band of the optical spectrum and generate strong photoacoustic response. These
contrast agents, which can be specifically targeted to molecules or cells, have been coupled with photoacoustic imaging for
preclinical and clinical applications ranging from detection of cancer cells, sentinel lymph nodes, and micrometastasis to
angiogenesis to characterization of atherosclerotic plaques. Multi-functional agents have also been developed, which can carry
drugs or simultaneously provide contrast in multiple imaging modalities. Furthermore, contrast agents were used to guide and
monitor the therapeutic procedures. Overall, photoacoustic imaging shows significant promise in its ability to assist in diagnosis,
therapy planning, and monitoring of treatment outcome for cancer, cardiovascular disease, and other pathologies. |
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Keywords: | |
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