| 超氧化物歧化酶、过氧化脂质和谷胱甘肽过氧化物酶变化与急性有机磷农药中毒的关系 |
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| 引用本文： | 张博,李光明,汤伯基,陈永桂,高凤喜.超氧化物歧化酶、过氧化脂质和谷胱甘肽过氧化物酶变化与急性有机磷农药中毒的关系[J].标记免疫分析与临床,1996(1). |
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| 作者姓名： | 张博 李光明 汤伯基 陈永桂 高凤喜 |
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| 作者单位： | 武警上海市总队医院内一科，武警上海市总队医院核医学研究所 |
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| 摘 要： | 本文对３３例急性有机磷农药中毒（ＡＯＩＰ）患者检测了超氧化物歧化酶（ＳＯＤ－１），过氧化脂质（ＬＰＯ）和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ），ＡＯＩＰ组的ＳＯＤ－１、ＧＳＨ－Ｐｘ较对照组明显降低（Ｐ＜０．０１）。而ＬＰＯ较对照组明显升高（Ｐ＜０．０１）。ＳＯＤ－１含量与胆碱酯酶活性呈正相关（ｒ＝０．６０２，Ｐ＜０．０１）。研究结果说明，氧自由基参于了有机磷农药对机体的损伤过程。
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| 关 键 词： | 杀虫剂．有机磷，超氧化物歧化酶类，过氧化脂质类，谷胱甘肽过氧化物酶类 |
Changes of Superoxide Dismutase, Lipid Peroxide and Glutathione Peroxidase in Acutc Organophosphorus Insecticide Poisoning |
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| Chang Bo,Li Guangming,Tang Baiji,et al..Changes of Superoxide Dismutase, Lipid Peroxide and Glutathione Peroxidase in Acutc Organophosphorus Insecticide Poisoning[J].Labeled Immunoassays and Clinical Medicine,1996(1). |
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| Authors: | Chang Bo Li Guangming Tang Baiji |
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| Abstract: | Superoxide dismutase (SOD-1),lipid peroxide (LPO),glutathione peroxidase (GSH-Px) were measurud in 33 patients with acute organophosphorus insecticide poisoning(AOIP)and 31 normal subjects.The results indicated that SOD-1,GSH-Px in patients with AOIP was significantly decreased than those of controls(P<0.01)and LPO in patients with AOIP was significantly higher than that of normals(P<0.01 ).SOD-1 was positively correlated with choline esterase activity (r=0.602,P<0.01).Our findings suggest that oxygen free radicals are involved in the injury caused by AOIP and the antioxidation agent may be used in the treatment. |
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| Keywords: | Insecticides organophosphate Superoxide dismutase Lipid peroxides Glutathione peroxidase |
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