多囊卵巢综合征患者血清前列腺特异抗原水平

研究多囊卵巢综合征（PCOS）患者血清前列腺特异抗原（PSA）是否升高。正常对照组50名,PCOS组40例,分别测定血清PSA、睾酮（T）、性激素结合球蛋白（SHBG）、硫酸脱氢表雄酮（DHEA-S）水平,对两组测定值进行统计学分析。正常对照组血清PSA值为3.56±0.44pg/mL,PCOS组为15.64±3.36pg/mL,两组值有显著性差异（P〈0.01）。血清PSA值与T、DHEA-S值之间有弱的正相关关系（分别为r=0.467P〈0.01;r=0.205,P〈0.05）;与SHBG值之间有弱负相关关系（r=-0.260,P〈0.05）。PCOS患者血清PSA水平高于正常人,PSA可作为女性雄激素增高的标志物而在临床应用。

The Serum Level of Prostate Specific Antigen in Polycystic Ovary Syndrome

To determine whether serum prostate specific antigen（PSA） level are increased in polycystic ovary syndrome（PCOS）,40 patients with PCOS,and 50 healthy control subjects were enrolled in the study.The subjects were compared by means of serum PSA T SHBG DHEA-S levels.The correlations between PSA and T SHBG DHEA-S were evaluated.Serum PSA levels were found to be significantly higher in PCOS（PSA： 15.64±3.36 pg/mL,in PCOS;PSA： 3.56±0.44pg/mL,in control;P0.01）.Positive correlations between PSA and T（r=0.467,P0.01） and between PSA and DHEA-S（r=,0.205 P0.05） were found.A negative correlation between PSA and SHBG was apparent（r=-0.260,P0.05）.Females with PCOS tended to have higher PSA than females without PCOS（P0.01）.PSA appears to be a promising marker of androgen excess in females suffering from PCOS.