| 慢性疲劳综合征患者外周血淋巴细胞亚群及CD25^＋调节性T细胞表达的研究 |
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| 引用本文： | 刘定华,刘占东,李永哲,张海莹,胡朝军,张拥波,王得新.慢性疲劳综合征患者外周血淋巴细胞亚群及CD25^＋调节性T细胞表达的研究[J].标记免疫分析与临床,2011,18(2):93-96. |
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| 作者姓名： | 刘定华 刘占东 李永哲 张海莹 胡朝军 张拥波 王得新 |
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| 作者单位： | 刘定华,LIU Ding-hua(中国医学科学院,北京协和医学院,北京协和医院检验科,北京100730);刘占东,张拥波,王得新,LIU Zhan-dong,ZHANG Yong-bo,WANG De-xin(首都医科大学附属北京友谊医院神经内科,北京,100050);李永哲,张海莹,胡朝军,LI Yong-zhe,ZHANG Hai-ying,HU Chao-jun(中国医学科学院,北京协和医学院,北京协和医院风湿免疫科,北京100730) |
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| 基金项目： | 国家高技术研究发展技划(863计划)基金资助项目 |
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| 摘 要： | 研究慢性疲劳综合征（CFS）患者外周血淋巴细胞亚群及CD25＋调节性T细胞的表达情况。使用流式细胞仪检测84例CFS患者（CFS组）、50例健康体检者（健康对照组）外周血淋巴细胞亚群（T细胞、CD4＋T细胞、CD8＋T细胞、B细胞、NK细胞）及CD25＋调节性T细胞的表达情况。结果显示,CFS组与健康对照组的T细胞、CD8＋T细胞百分率以及CD4＋/CD8＋比值无显著差别（P〉0.05）;而CFS组NK细胞、CD4＋T细胞及CD25＋调节性T细胞百分率显著增高,B细胞百分率显著降低（P〈0.05）。结论：慢性疲劳综合征患者外周血淋巴细胞各亚群比例异常,提示其免疫功能失衡,而CD25＋T调节性细胞可能在该病进程中有重要意义。
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| 关 键 词： | 慢性疲劳综合征 淋巴细胞 CD25＋调节性T细胞 流式细胞术 |
Expression of Lymphocyte Subsets and CD25+ Regulative T Cells in Peripheral Blood of Patients with Chronic Fatigue Syndrome |
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| LIU Ding-hua,LIU Zhan-dong,LI Yong-zhe,ZHANG Hai-ying,HU Chao-jun,ZHANG Yong-bo,WANG De-xin.Expression of Lymphocyte Subsets and CD25+ Regulative T Cells in Peripheral Blood of Patients with Chronic Fatigue Syndrome[J].Labeled Immunoassays and Clinical Medicine,2011,18(2):93-96. |
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| Authors: | LIU Ding-hua LIU Zhan-dong LI Yong-zhe ZHANG Hai-ying HU Chao-jun ZHANG Yong-bo WANG De-xin |
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| Institution: | (Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China) |
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| Abstract: | To investigate the expression of lymphocyte subsets and CD25+ regulative T cells in peripheral blood of patients with chronic fatigue syndrome(CFS).Eighty-four CFS patients and fifty healthy volunteers were enrolled in this study.Their peripheral blood was sampled,and the lymphocyte subsets and CD25+ regulative T cells were measured by flow cytometry.The results showed that the NK cells,CD4+T cells and CD25+ regulative T cells in CFS patients were higher and B cells were lower than that of healthy controls(P<0.05),while there was no significant difference between CFS patients and healthy controls with respect to the percentage of T cells and CD8+T cells and CD4+/CD8+ ratio(P>0.05).The results indicated that CD25+ regulative T cell might play an important role in CFS-related immunological abnormality,and be involved in the progress of CFS. |
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| Keywords: | Chronic fatigue syndrome Lymphocyte Regulative T cell Flow cytometry |
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