缺血修饰白蛋白、肌钙蛋白、肌红蛋白、肌酸激酶同工酶检测在急性冠状动脉综合征早期发现中的应用

目的 探讨缺血修饰白蛋白（IMA）、肌钙蛋白（cTnⅠ）、肌红蛋白（MYO）、肌酸激酶同工酶（CK-MB）检测在急性冠状动脉综合征的早期发现中的应用价值.方法 选择100例急性冠状动脉综合征（ACS）患者,在胸痛发作后3小时内检测缺血修饰白蛋白（IMA）、肌钙蛋白（cTnl）、肌红蛋白（MYO）,肌酸激酶同工酶（CK-MB）,同时选择100例健康查体者为对照组,做相同检测,观察各种心肌标志物的变化.结果 ACS组与对照组的检测结果进行对比,4项指标的差异均具有统计学意义（P＜0.05）.ROC下曲线面积显示,IMA仅次于cTnⅠ,高于MYO和CK-MB.结论 IMA、MYO、cTnⅠ、CK-MB联合检测在急性冠脉综合征（ACS）早期诊断中具有重要的临床意义.

Clinical Values of IMA,cTnⅠ, MYO and CK-MB in Early Diagnosis of Acute Coronary Syndrome

Objective To explore the clinical value of Ischemia modified albumin （IMA）, Cardiac troponin I （cTnI） ,Myohemoglobin （MYO） and Creatine kinasc isozymes （CK-MB） detection in the early diagnosis of acute coronary syndrome（ACS）. Methods The serum levels of IMA, cTnI, MYO and CK-MB in 100 patients with acute coronary syndrome （ACS） at 3 hours after chest pain and in 100 healthy cases were detected. Results There were significantly difference on the IMA, cTnI, MYO and CK-MB between ACS group and control group （P 〈 0.05 ）. The areas under ROC curve in ACS group was lower than cTnI, but higher than MYO and CK-MB. Conclusion The combined detection of IMA, cTnI, MYO and CK-MB in acute coronary syndrome have a significant clinical value in the early diagnosis of ACS.