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Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever |
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| Authors: | Buijs Sheila B Stuart Sanne K Oosterheert Jan Jelrik Karhof Steffi Hoepelman Andy I M Renders Nicole H M van Petersen André S Bleeker-Rovers Chantal P Wever Peter C Koning Olivier H J |
| Institution: | 1.Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands ;2.Department of Surgery, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands ;3.Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, ’s-Hertogenbosch, The Netherlands ;4.Department of Surgery, Bernhoven Hospital, Uden, The Netherlands ;5.Department of Internal Medicine and Infectious Diseases, Radboud Expert Centre for Q Fever, Radboud University Medical Center, Nijmegen, The Netherlands ; |
| Abstract: | We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation. |
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