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| 人参皂苷Rg1与Rh1对树突状细胞表达HLA-DR、CD25、CD44、CD54、CD11c及E-selectin的影响 | |
| 引用本文： | 王毅,郝钰,邱全瑛,黄启福.人参皂苷Rg1与Rh1对树突状细胞表达HLA-DR、CD25、CD44、CD54、CD11c及E-selectin的影响[J].中国免疫学杂志,2007,23(1):46-48,52. |
| 作者姓名： | 王毅 郝钰 邱全瑛 黄启福 |
| 作者单位： | 1. 中国中医科学院医学实验中心,北京,100700 2. 北京中医药大学微生物免疫教研室,北京,100029 3. 北京中医药大学病理教研室,北京,100029 |
| 摘 要： | 目的：观察人参皂苷Rg1和Rh1对树突状细胞（Dendritic cell，DC）表面分子CD25、HLA-DR、CD44、ICAM-1、CD11c及E-sclectin表达的影响。方法：用不同浓度的Rg1和Rh1分别加入成熟DC中，刺激一定时间后，用免疫组化法观察，并用图像分析法分析结果。结果：除E-selectin外，Rg1和Rh1均可不同程度地促进HLA—DR、CD25、CD11c、CD44和ICAM-1的表达。结论：Rg1、Rh1可增强DC表面促进T细胞活化的第一、二类信号系统分子的表达，提高其抗原递呈能力，并促进DC—T细胞簇的形成而活化初始T细胞。 |
| 关 键 词： | 树突状细胞 人参皂苷 |
| 文章编号： | 1000-484X（2007）01-0046-04 |
| 修稿时间： | 2006-03-22 |
Effect of Ginsenoside Rg1 and Rh1 on the expression of HLA-DR,CD25,CD44, CD11c and E-selectin on dendritic cell |
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| WANG Yi,HAO Yu,QIU Quan-Ying,HUANG Qi-Fu.Effect of Ginsenoside Rg1 and Rh1 on the expression of HLA-DR,CD25,CD44, CD11c and E-selectin on dendritic cell[J].Chinese Journal of Immunology,2007,23(1):46-48,52. | |
| Authors: | WANG Yi HAO Yu QIU Quan-Ying HUANG Qi-Fu |
| Institution: | Microbiology and Immunology Department, Beijing University of Chinese Medicine, Beijing 100029, China |
| Abstract: | Objective:To test the effect of Ginsenoside Rg1 and Rh1 on the expression of CD25,HLA-DR,CD44,ICAM-1,CD11c and E-selectin on the surface of dendritic cell(DC).Methods:Mature DCs were treated with different doses of Rg1 and Rh1. Certain time later, the expression of adhesion molecular was detected with immunohistochemical method and the results were recorded with imaging data.Results:Except for E-selectin, both of Rg1 and Rh1 could increase the expression of HLA-DR,CD25,CD11c,CD44 and ICAM-1 on DCs.Conclusion:Expression increase of surface molecular, including in two signals required by T cell activation, stimulated by Rg1 and Rh1, is propitious to the formation of DC- T cell cluster that would enhance the antigen-presenting function of DC. |
| Keywords: | CD25 HLA-DR CD44 ICAM-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |