CDX2和Villin在胃黏膜病变中的表达及其临床病理意义

目的:探讨CDX2和Villin在胃黏膜病变中的表达及其临床病理意义和诊断作用.方法:收集2015年1月至2017年5月本院胃黏膜活检标本90例,其中慢性胃炎21例,慢性胃病伴肠上皮化生22例,胃上皮内瘤变25例,胃癌22例.采用免疫组织化学方法检测CDX2和Villin蛋白在胃黏膜活检组织中的表达.结果:CDX2及Villin在慢性胃病伴肠上皮化生组、胃上皮内瘤变组及胃癌组均有高表达,其阳性率显著高于慢性胃炎组,差异有统计学意义(P<0.01);CDX2与Villin的表达存在正相关(P<0.01).结论:CDX2和Villin异常表达于胃黏膜肠上皮化生、胃上皮内瘤变及胃癌组织中,提示两者可能在胃癌(特别是肠型胃癌)的发生中起重要意义,同时在胃黏膜活检中诊断胃癌及癌前病变(尤其是形态学难以确定)时,两者联合检测可以作为辅助诊断的依据.

Expression of CDX2 and Villin in gastric mucosal lesions and their clinical pathologic significance

Objective: To investigate the expression of CDX2 and Villin in gastric mucosal lesions and their clinicopathological significance and diagnostic role. Methods: Ninety cases of gastric mucosa biopsy specimens in total, including 21 cases of chronic gastritis, 22 cases of chronic stomach disease associated with intestinal metaplasia, 25 cases of gastric intraepithelial neoplasia, and gastric carcinoma 22 cases, were collected from our hospital from January 2015 to May 2017. The immunohistochemical methods were used to detect the expression of CDX2 and Villin in the gastric mucosal biopsy tissue. Results: CDX2 and Villin had high expression in patients with intestinal metaplasia,gastric intraepithelial neoplasia and gastric cancer, and their positive rate was significantly higher than that of chronic gastritis, the differences were statistically significant (P<0.01). CDX2 was positively correlated with Villin (P<0.01).Conclusion: Both CDX2 and Villin are expressed in the intestinal metaplasia, gastric intraepithelial neoplasia and gastric cancer tissue, suggesting that the two may play an important role in the occurrence of gastric cancer (especially gastrointestinal carcinoma), at the same time, it can be used as the basis for the auxiliary diagnosis of gastric cancer and precancerous lesions (especially morphology is difficult to determine).