糖耐量减低的绝经后女性血浆和肽素水平与血糖的相关性

目的:观察糖耐量减低的绝经后女性血浆和肽素水平与血糖的相关性.方法:将80例新发糖耐量减低(空腹血糖≤6.2 mmol/L,7.8 mmol/L≤甲餐后2h血糖≤9.4 mmol/L)的绝经后女性,年龄56～59岁,依据基线时和肽素水平,分成A组(＜5 pmol/L)、B组(＞20 pmol/L组),每组各40例.分析两组间基线时和6个月后和肽素、血糖的差异.结果:基线时,A组与B组组间的和肽素差异有统计学意义(P＜0.05),而在体重、空腹全血血糖、早餐后2h血糖、空腹血清三酰甘油、血清总胆固醇、血清低密度脂蛋白胆固醇、平均动脉压、血清肌酐水平、年龄等指标上结果相似,差异无统计学意义.经调整生活方式及口服阿司匹林(100 mg/d)、瑞舒伐他汀(10 mg/d)6个月后,在和肽素水平、空腹血糖、早餐后2h血糖指标上,B组明显高于A组,差异有统计学意义(P＜0.05).B组中有新发糖尿病16例,而A组没有.结论:在糖耐量减低的绝经后女性中,高血浆和肽素水平会进一步加重糖耐量减低,促使糖尿病的发生.

Association of copeptin levels with blood glucose in postmenopausal women with impaired glucose tolerance

Objective:To observe the association of copeptin levels with blood glucose in postmenopausal women with impaired glucose tolerance.Methods:Eighty postmenopausal women,aged 56-59 years,with the onset of impaired glucose tolerance (i.e.,fasting blood glucose ≤ 6.2 mmol/L,7.8 mmol/L ≤ 2-hour postprandial blood glucose ≤ 9.4 mmol/L),were divided into a group A (copeptin ＜5 pmol/L) and a group B (copeptin ＞20 pmol/L),according to serum copeptin levels at baseline,40 cases in each group.The differences of copeptin and blood glucose were analyzed between the two groups at baseline and after 6-month follow-up.Results:At baseline,the difference was statistically significant in copeptin levels (P＜0.05),but not in weight,fasting blood glucose,2-hour postprandial blood glucose,fasting serum TG,total serum TC,serum LDL-C,mean arterial pressure,serum creatinine and age between group A and group B (P＞0.05).After 6-month therapeutic lifestyle adjustment as well as oral administration of aspirin (100 mg/d) and rosuvastatin (10 mg/d),copeptin level,fasting blood glucose and 2-hour postprandial blood glucose of group B was statistically significantly higher,compared with group A,respectively (P＜0.05).Furthermore,16 cases developed diabetes in group B,while not in group A.Conclusion:On the basis of the influence of the risk factors of impaired glucose tolerance and postmenopausal female,high plasma copeptin level will further aggravate impaired glucose tolerance and promote the onset of diabetes.