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生物钟基因Timeless及与肿瘤关系的研究进展
引用本文:张金玲,吴超.生物钟基因Timeless及与肿瘤关系的研究进展[J].国际病理科学与临床杂志,2017,37(5).
作者姓名:张金玲  吴超
作者单位:临沂市莒南县人民医院消化内科,山东临沂,276600
基金项目:中央高校基本科研业务费专项资金:华中科技大学自主创新基金,中国肝炎防治基金会-天晴肝病研究基金(TQGB2017005).This work was supported by the Fundamental Research Funds for the Central Universities:the Independent Innovation Fund of Huazhong University of Science and Technology,Chinese Foundation for Hepatitis Prevention and Control-TianQing Liver Disease Research Fund Subject,China
摘    要:生物钟基因的功能不仅局限于调节生物节律,更与细胞内DNA的修复、细胞的增殖等一系列过程相关联,Timeless是生物钟基因成员之一,对Timeless基因的研究起步较晚.近年来研究发现生物钟基因在多种肿瘤中普遍存在表达异常,而对Timeless研究较少.

关 键 词:Timeless  生物钟  基因  肿瘤

Research progress in relationship between Timeless and tumor
ZHANG Jinling,WU Chao.Research progress in relationship between Timeless and tumor[J].Journal of International Pathology and Clinical Medicine,2017,37(5).
Authors:ZHANG Jinling  WU Chao
Abstract:The function of clock genes is not only confined to adjust biological rhythm,but also has a great relationship with cell proliferation and DNA repair in cells.Timeless is a member of clock genes,but the study on Timeless started late relatively.In recent years,some study found that the circadian dock genes have an abnormal expression in a variety of tumors.But among these study,researches on Timeless are less.Therefore,this article summarized the domestic and foreign researches on Timeless for a review,and discussed the relationship between Timeless and tumor.
Keywords:Timeless  circadian clock  gene  tumor
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