PRSS3-mRNA与长链非编码RNA-PRSS3P2在甲状腺乳头状癌组织中的表达及其临床意义

目的:检测PRSS3-mRNA及lncRNA-PRSS3P2在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)及癌旁甲状腺组织中的表达特点,探讨二者在PTC中表达的临床病理意义.方法:收集2016年7至10月本院55例PTC及癌旁甲状腺组织的新鲜手术标本,应用荧光实时定量PCR检测PRSS3-mRNA及lncRNA-PRSS3P2在PTC和癌旁组织中表达情况,并分析其与临床病理特征的相关性.结果:PRSS3-mRNA及lncRNA-PRSS3P2在PTC组织中表达均明显高于非肿瘤组织;PRSS3P2的表达与患者的年龄相关(P＜0.05),而PRSS3与各种临床病理特征无明显相关性.结论:在PTC组织中,PRSS3-mRNA和lncRNA-PRSS3P2的表达均明显升高,这提示二者可能参与了PTC的发病过程;PRSS3-mRNA和lncRNA-PRSS3P2可以作为PTC的诊断标志物进行进一步研究.

Expression and clinical significance of PRSS3-mRNA and LncRNA-PRSS3P2 in papillary thyroid carcinoma

Objective:To detect the expressions of PRSS3-mRNA and lncRNA-PRSS3P2 in PTCs and their corresponding normal thyroid tissues,and to explore the clinicopathologic significance of PRSS3 and PRSS3P2 in PTC.Methods:A total of 55 fresh tissues of PTC plus with their paired normal thyroid tissues resected between July 1 and October 31,2016 were collected.The expressions of PRSS3-mRNA and lncRNA-PRSS3P2 were detected by real-time quantitative PCR.The relationship between expressions of PRSS3/PRSS3P2 and the clinicopathologic features were carefully analyzed.Results:The expression levels of PRSS3 and PRSS3P2 in PTC tissues were obviously higher than their non-tumor counterparts (P＜0.05).PRSS3P2 was correlated with the age of patients (P＜0.05);however,PRSS3 is not associated with the clinicopathologic features of PTC.Conclusion:The expressions of PRSS3-mRNA and lncRNA-PRSS3P2 were increased in PTC.The present findings indicate that PRSS3 and PRSS3P2 may participate the development of PTC.PRSS3-mRNA and lncRNA-PRSS3P2 can be served as two potential diagnostic markers for PTC.